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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36616: 2-oxoglutarate dehydrogenase, E1 component

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphoketolase. [EC: 4.1.2.9]
D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H(2)O.
    		 510 A0A060QEC5 A0A060QEC5 A0A061CHQ4 A0A061CHQ4 A0A061CIB3 A0A061CIB3 A0A062XNU7 A0A062XNU7 A0A073CF52 A0A073CF52
    (500 more...)
    Fructose-6-phosphate phosphoketolase. [EC: 4.1.2.22]
    D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H(2)O.
    • Also acts on D-xylulose 5-phosphate.
    		 378 A0A060QEC5 A0A060QEC5 A0A062XNU7 A0A062XNU7 A0A072N5R3 A0A072N5R3 A0A073CGC7 A0A073CGC7 A0A083XW22 A0A083XW22
    (368 more...)
    Acetate kinase. [EC: 2.7.2.1]
    ATP + acetate = ADP + acetyl phosphate.
    • While purified enzyme from Escherichia coli is specific for acetate, others have found that the enzyme can also use propanoate as a substrate, but more slowly.
    • Acetate can be converted into the key metabolic intermediate acetyl- CoA by coupling acetate kinase with EC 2.3.1.8.
    • Both this enzyme and EC 2.7.2.15 play important roles in the production of propanoate.
    		 12 A0A0D6QF07 A0A0D6QF07 A7HC95 A7HC95 B4UM11 B4UM11 B8JHD2 B8JHD2 M9M074 M9M074
    (2 more...)
    Transketolase. [EC: 2.2.1.1]
    Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
    • Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH.
    • The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.
    		 4 A0A0F4YMC7 A0A0F4YMC7 A2QDB0 A2QDB0