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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36582: Pyruvate decarboxylase isozyme 1

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyruvate decarboxylase. [EC: 4.1.1.1]
A 2-oxo acid = an aldehyde + CO(2).
  • Also catalyzes acyloin formation.
 766 A0A009GL29 A0A009GL29 A0A009H6K1 A0A009H6K1 A0A009HTP2 A0A009HTP2 A0A009JVK7 A0A009JVK7 A0A009MMI6 A0A009MMI6
(756 more...)
Indolepyruvate decarboxylase. [EC: 4.1.1.74]
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).
  • More specific than EC 4.1.1.1.
 706 A0A009H6K1 A0A009H6K1 A0A009HTP2 A0A009HTP2 A0A009JVK7 A0A009JVK7 A0A060V9P3 A0A060V9P3 A0A062EUC5 A0A062EUC5
(696 more...)
Acetolactate synthase. [EC: 2.2.1.6]
2 pyruvate = 2-acetolactate + CO(2).
  • The reaction shown is in the pathway of biosynthesis of valine.
  • The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.
  • Formerly EC 4.1.3.18.
 68 A0A089SB96 A0A089SB96 A0A0E8VIK8 A0A0E8VIK8 A0A0G4DW04 A0A0G4DW04 A0A0G7HFJ4 A0A0G7HFJ4 A0A0H3LFY1 A0A0H3LFY1
(58 more...)
Phenylpyruvate decarboxylase. [EC: 4.1.1.43]
Phenylpyruvate = phenylacetaldehyde + CO(2).
  • Also acts on (indol-3-yl)pyruvate.
 18 A0A0L8VLD5 A0A0L8VLD5 A7A0U9 A7A0U9 B3LT15 B3LT15 E7KFE4 E7KFE4 E7LXD6 E7LXD6
(8 more...)
Thiol oxidase. [EC: 1.8.3.2]
2 R'C(R)SH + O(2) = R'C(R)S-S(R)CR' + H(2)O(2).
  • R may be =S or =O, or a variety of other groups.
  • The enzyme is not specific for R'.
 6 A0A0G4L7I7 A0A0G4L7I7 A0A0G4LVP3 A0A0G4LVP3 G0SB10 G0SB10
Sulfoacetaldehyde acetyltransferase. [EC: 2.3.3.15]
Acetyl phosphate + sulfite = 2-sulfoacetaldehyde + phosphate.
  • The reaction occurs in the reverse direction to that shown above.
 2 A0A0T9YHE4 A0A0T9YHE4
Cyclohexane-1,2-dione hydrolase. [EC: 3.7.1.11]
Cyclohexane-1,2-dione + H(2)O = 6-oxohexanoate.
  • Highly specific; does not act on cyclohexanone or cyclohexane-1,3- dione as substrate.
 2 P0CH62 P0CH62