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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36565: Transketolase 1, thiamin-binding protein

There are 10 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Transketolase. [EC: 2.2.1.1]
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
  • Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH.
  • The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.
 13304 A0A009FBH7 A0A009GDL9 A0A009GML9 A0A009HJF3 A0A009HR38 A0A009JZ07 A0A009KDL9 A0A009KPK7 A0A009MP94 A0A009Q1U3
(13294 more...)
Formaldehyde transketolase. [EC: 2.2.1.3]
D-xylulose 5-phosphate + formaldehyde = D-glyceraldehyde 3-phosphate + glycerone.
  • Also converts hydroxypyruvate and formaldehyde into glycerone and CO(2).
  • Not identical with EC 2.2.1.1.
 40 A0A084FWV9 A0A084G7S0 A0A086KGB5 A0A086KGC7 A0A086PMR9 A0A0A1UAR3 A0A0C1YGN1 A0A0C2CGY7 A0A0F4Z5V0 A0A0L1HG22
(30 more...)
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring). [EC: 1.2.4.4]
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine- residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO(2).
  • It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2- oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine.
  • It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168, which also binds multiple copies of EC 1.8.1.4.
  • It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.168.
  • Formerly EC 1.2.4.3.
 11 A0A1H6PAP7 J9DC41 J9GGE6 T0YRU9 T0Z7P5 T0ZVN6 T1A1U2 T1A5A8 T1A9H9 T1ANB7
(1 more...)
Transaldolase. [EC: 2.2.1.2]
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.
    		 7 A0A013XWA4 A0A059KHZ1 A0A0K1EKM9 B1XX41 D8E2M2 L0GU76 U7MNT7
    Capsanthin/capsorubin synthase. [EC: 5.3.99.8]
    (1) Violaxanthin = capsorubin. (2) Antheraxanthin = capsanthin.
    • Induced during chromoplast differentiation in plants.
    • Isomerization of the epoxide ring of violaxanthin gives the cyclopentyl-ketone of capsorubin or capsanthin.
    		 4 A0A0H3AQ76 C0G8C5 C4ISU2 C4WLR5
    1-deoxy-D-xylulose-5-phosphate synthase. [EC: 2.2.1.7]
    Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO(2).
    • The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
    • Formerly EC 4.1.3.37.
    		 4 A0A0P8A5X4 A0A1L7RJK6 A0A1L7RM46 F8C2Z0
    Dihydroxy-acid dehydratase. [EC: 4.2.1.9]
    2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H(2)O.
      		 4 A0A0B7L3X5 A5M8H8 C1CH61 D6ZNG7
      Ribulose-phosphate 3-epimerase. [EC: 5.1.3.1]
      D-ribulose 5-phosphate = D-xylulose 5-phosphate.
      • Also converts D-erythrose 4-phosphate into D-erythrulose 4-phosphate and D-threose 4-phosphate.
      		 2 A0A0N9Z2B1 A0A128A5E5
      Isoleucine--tRNA ligase. [EC: 6.1.1.5]
      ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl- tRNA(Ile).
        		 1 U2WRV2
        Glucose-6-phosphate isomerase. [EC: 5.3.1.9]
        D-glucose 6-phosphate = D-fructose 6-phosphate.
        • Also catalyzes the anomerization of D-glucose 6-phosphate.
        		 1 A0A1F2QF61