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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36363: Acetolactate synthase large subunit

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Acetolactate synthase. [EC: 2.2.1.6]
2 pyruvate = 2-acetolactate + CO(2).
  • The reaction shown is in the pathway of biosynthesis of valine.
  • The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.
  • Formerly EC 4.1.3.18.
 2054 A0A011TYL1 A0A011TYL1 A0A022NBN6 A0A022NBN6 A0A023E1P5 A0A023E1P5 A0A023P3G0 A0A023P3G0 A0A031IHE5 A0A031IHE5
(2044 more...)
Transferred entry: 2.2.1.6. [EC: 4.1.3.18]
    		6 P94896 P94896 Q8L209 Q8L209 Q9ZIA9 Q9ZIA9
    N(2)-(2-carboxyethyl)arginine synthase. [EC: 2.5.1.66]
    D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L- arginine + phosphate.
    • Requires thiamine diphosphate and catalyzes the first step in the clavulanic-acid biosynthesis pathway.
    • The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.
    		 2 A0A1D7ZUG7 A0A1D7ZUG7