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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36158: Pyruvate-flavodoxin oxidoreductase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyruvate synthase. [EC: 1.2.7.1]
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
  • The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
 48 A0A0B0EKT6 A0A0E0T614 A0A0E1L260 A0A0H3A501 A0A0T9WJF1 A0A126QNC1 A0A126QNZ6 A0A150J954 A0A175LAY6 A0A1E7I0Y9
(38 more...)
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). [EC: 1.2.7.7]
3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+).
  • Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo- pentanoate, 2-oxobutyrate and 3-methylthiopropanamine.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.1 and EC 1.2.7.3.
 7 A0A150ILV2 A0A150ISV7 A0A150IZZ7 A0A150J8T5 A0A150JBD2 A0A150JGL2 A0A150JJ74
Pyruvate dehydrogenase (NADP(+)). [EC: 1.2.1.51]
Pyruvate + CoA + NADP(+) = acetyl-CoA + CO(2) + NADPH.
  • The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly.
  • Inhibited by oxygen.
 1 Q94IN5
Aquacobalamin reductase (NADPH). [EC: 1.16.1.5]
2 cob(II)alamin + NADP(+) + 2 H(2)O = 2 aquacob(III)alamin + NADPH.
  • Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin.
  • Formerly EC 1.6.99.11.
 1 Q94IN5