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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 35932: Putative pyruvate-flavodoxin oxidoreductase domain...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyruvate synthase. [EC: 1.2.7.1]
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
  • The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
 152 A0A015NVJ1 A0A015NVJ1 A0A085TCH0 A0A085TCH0 A0A0B0EKT6 A0A0B0EKT6 A0A0B1TTU8 A0A0B1TTU8 A0A0E0T614 A0A0E0T614
(142 more...)
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). [EC: 1.2.7.7]
3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+).
  • Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo- pentanoate, 2-oxobutyrate and 3-methylthiopropanamine.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.1 and EC 1.2.7.3.
 14 A0A150ILV2 A0A150ILV2 A0A150ISV7 A0A150ISV7 A0A150IZZ7 A0A150IZZ7 A0A150J8T5 A0A150J8T5 A0A150JBD2 A0A150JBD2
(4 more...)
Pyruvate dehydrogenase (NADP(+)). [EC: 1.2.1.51]
Pyruvate + CoA + NADP(+) = acetyl-CoA + CO(2) + NADPH.
  • The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly.
  • Inhibited by oxygen.
 12 A0A0A1TYU8 A0A0A1TYU8 A0A0A1UF84 A0A0A1UF84 B0E6B9 B0E6B9 B6AEJ2 B6AEJ2 Q94IN5 Q94IN5
(2 more...)
Aquacobalamin reductase (NADPH). [EC: 1.16.1.5]
2 cob(II)alamin + NADP(+) + 2 H(2)O = 2 aquacob(III)alamin + NADPH.
  • Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin.
  • Formerly EC 1.6.99.11.
 2 Q94IN5 Q94IN5