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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 57391: Oxidoreductase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glucose 1-dehydrogenase (NAD(P)(+)). [EC: 1.1.1.47]
D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H.
  • This enzyme has similar activity with either NAD(+) or NADP(+).
  • Cf. EC 1.1.1.118 and EC 1.1.1.119.
 8 A0A0E1LQY8 A0A0K6JP38 A0A0K6L826 A0A0T8PKD3 A0A1L3PRX3 A0A1N7DGM5 A7Z3Z1 I2C499
Diacetyl reductase ((R)-acetoin forming). [EC: 1.1.1.303]
(R)-acetoin + NAD(+) = diacetyl + NADH.
  • The reaction is catalyzed in the reverse direction.
  • This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76).
  • While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible.
  • This enzyme has been reported in the yeast Saccharomyces cerevisiae.
  • Different from EC 1.1.1.304.
  • Formerly EC 1.1.1.5.
 3 A0A0T8PKD3 A0A0U0D9E0 A0A1L3QYB6
Diacetyl reductase ((S)-acetoin forming). [EC: 1.1.1.304]
(S)-acetoin + NAD(+) = diacetyl + NADH.
  • The reaction is catalyzed in the reverse direction.
  • This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76).
  • While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible.
  • This enzyme has been reported in the bacteria Geobacillus stearothermophilus, Enterobacter aerogenes and Klebsiella pneumoniae.
  • Different from EC 1.1.1.303.
  • Formerly EC 1.1.1.5.
 2 A0A0U0D9E0 A0A1L3QYB6
3-oxoacyl-[acyl-carrier-protein] reductase. [EC: 1.1.1.100]
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
  • Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.
 1 A0A0K0I3A6