The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 52971: Putative short-chain type dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-(S)-hydroxypropyl-CoM dehydrogenase. [EC: 1.1.1.269]
2-(S)-hydroxypropyl-CoM + NAD(+) = 2-oxopropyl-CoM + NADH.
  • Highly specific for (S)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.268, which is highly specific for the (R)-enantiomer.
  • Forms component IV of a four-component enzyme system (comprising EC 4.4.1.23 (component I), EC 1.8.1.5 (component II), EC 1.1.1.268 (component III) and EC 1.1.1.269 (component IV)) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
17 A0A045IYW4 A0A083W992 A0A0G4E049 A0A0H3L9N0 A0A0H3MB94 A0A0H3P3S6 A0A0K2HWE8 A0A109SNJ3 A0A1K5DRY9 A0A1K7L156
(7 more...)
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase. [EC: 1.1.1.53]
Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH.
  • The 3-alpha-hydroxy group or 20-beta-hydroxy group of pregnane and androstane steroids can act as donor.
2 A0A0T9YD65 A0A1K6TGV3