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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 292294: Homolog to ornithine cyclodeaminase

There are 10 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Ornithine cyclodeaminase. [EC: 4.3.1.12]
L-ornithine = L-proline + NH(3).
  • The enzyme is a member of the mu-crystallin protein family.
  • The reaction is stimulated by the presence of ADP or ATP and is inhibited by O(2).
 3628 A0A010Q4H5 A0A010Q4H5 A0A011TCL3 A0A011TCL3 A0A011UHV4 A0A011UHV4 A0A011VIT8 A0A011VIT8 A0A011VIT8 A0A011VIT8
(3618 more...)
Alanine dehydrogenase. [EC: 1.4.1.1]
L-alanine + H(2)O + NAD(+) = pyruvate + NH(3) + NADH.
    		 752 A0A017T0S9 A0A017T0S9 A0A062V0U9 A0A062V0U9 A0A063ZGZ9 A0A063ZGZ9 A0A075WE43 A0A075WE43 A0A076I5Q0 A0A076I5Q0
    (742 more...)
    L-lysine cyclodeaminase. [EC: 4.3.1.28]
    L-lysine = L-pipecolate + NH(3).
    • The enzyme produces the non-proteinogenic amino acid L-pipecolate, which is incorporated into multiple secondary metabolite products, including rapamycin, tobulysin, virginiamycin and pristinamycin.
    		 166 A0A063YVG3 A0A063YVG3 A0A075RE86 A0A075RE86 A0A0D0TJ90 A0A0D0TJ90 A0A0D1ELM5 A0A0D1ELM5 A0A0F0LBX8 A0A0F0LBX8
    (156 more...)
    1-pyrroline-2-carboxylate reductase (NAD(P)H). [EC: 1.5.1.49]
    L-proline + NAD(P)(+) = 1-pyrroline-2-carboxylate + NAD(P)H.
    • The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism.
    • In contrast to EC 1.5.1.1 which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter.
    • While the enzyme is active with both NADH and NADPH, activity is higher with NADPH.
    		 20 A0A150EKR5 A0A150EKR5 A0A164RHR0 A0A164RHR0 A0A1J9YE88 A0A1J9YE88 A1B196 A1B196 C2SWY9 C2SWY9
    (10 more...)
    Thiomorpholine-carboxylate dehydrogenase. [EC: 1.5.1.25]
    Thiomorpholine 3-carboxylate + NAD(P)(+) = 3,4-dehydro-thiomorpholine-3- carboxylate + NAD(P)H.
    • The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine.
    • In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, more slowly.
    		 16 A0A061IGJ9 A0A061IGJ9 A0A087DTL3 A0A087DTL3 O54983 O54983 Q14894 Q14894 Q28488 Q28488
    (6 more...)
    Glutamyl-tRNA reductase. [EC: 1.2.1.70]
    L-glutamate 1-semialdehyde + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH.
    • Forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway, which is used in most eubacteria, and in all archaebacteria, algae and plants.
    • However, in the alpha-proteobacteria EC 2.3.1.37 is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine.
    • This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium.
    • Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37.
    		 14 A0A0G4D7H6 A0A0G4D7H6 A0A0T8DBE4 A0A0T8DBE4 A0A0U0IN90 A0A0U0IN90 A0A1M2UFX0 A0A1M2UFX0 A0A1M6PAL8 A0A1M6PAL8
    (4 more...)
    Short-chain acyl-CoA dehydrogenase. [EC: 1.3.8.1]
    A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
    • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
    • The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R-hydrogen atoms.
    • The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms.
    • The highest activity was reported with either butanoyl-CoA or pentanoyl-CoA.
    • The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA.
    • Cf. EC 1.3.8.7, EC 1.3.8.8 and EC 1.3.8.9.
    • Formerly EC 1.3.2.1 and EC 1.3.99.2.
    		 4 A0A1J0NS59 A0A1J0NS59 I2AYL5 I2AYL5
    1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NAD(P)H). [EC: 1.5.1.1]
    (1) L-pipecolate + NAD(P)(+) = 1-piperideine-2-carboxylate + NAD(P)H. (2) L-proline + NAD(P)(+) = 1-pyrroline-2-carboxylate + NAD(P)H.
    • The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism.
    • In contrast to EC 1.5.1.21, which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.
    		 4 A0A140LE12 A0A140LE12 A0A162MTN8 A0A162MTN8
    Ethanolamine ammonia-lyase. [EC: 4.3.1.7]
    Ethanolamine = acetaldehyde + NH(3).
      		 4 A0A0P7WZM4 A0A0P7WZM4 G8QAW6 G8QAW6
      2,4-diaminopentanoate dehydrogenase. [EC: 1.4.1.12]
      (2R,4S)-2,4-diaminopentanoate + H(2)O + NAD(P)(+) = (2R)-2-amino-4- oxopentanoate + NH(3) + NAD(P)H.
        		 2 B9DPU3 B9DPU3