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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291961: Putative erythronate-4-phosphate dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
4-phosphoerythronate dehydrogenase. [EC: 1.1.1.290]
4-phospho-D-erythronate + NAD(+) = (3R)-3-hydroxy-2-oxo-4- phosphonooxybutanoate + NADH.
  • This enzyme catalyzes a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate.
  • The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD(+).
  • In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyzes the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)- hydroxy acid.
  • Cf. EC 1.1.1.399.
 10 A0A0A2SSP4 A0A128YLA6 A0A129G2S0 A0A129Z924 A0A131BZ05 G8UUM6 Q5EDM1 Q5WXZ0 Q5X6I6 Q5ZX15
(S)-sulfolactate dehydrogenase. [EC: 1.1.1.310]
(2S)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + NADH.
  • This enzyme, isolated from the bacterium Chromohalobacter salexigens DSM 3043, acts only on the (S)-enantiomer of 3-sulfolactate.
  • Combined with EC 1.1.1.338, it provides a racemase system that converts (2S)-3-sulfolactate to (2R)-3-sulfolactate, which is degraded further by EC 4.4.1.24.
  • The enzyme is specific for NAD(+).
 1 Q1QWN6