The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 291696: Glutamate dehydrogenase 1, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 30 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamate dehydrogenase [NAD(P)+] activity GO:0004353
Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
10 P00366 (/ISS) P00368 (/ISS) P10860 (/ISS) P54385 (/ISS) P82264 (/ISS) Q54KB7 (/ISS) Q5LSM4 (/ISS) Q81SY3 (/ISS) Q8T453 (/ISS) Q9VCN3 (/ISS)
Glutamate dehydrogenase (NAD+) activity GO:0004352
Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.
9 P00366 (/ISS) P27346 (/ISS) Q5HHC7 (/ISS) Q60A41 (/ISS) Q6GAW8 (/ISS) Q6GID0 (/ISS) Q7A1B9 (/ISS) Q7A6H8 (/ISS) Q99VD0 (/ISS)
Glutamate dehydrogenase (NAD+) activity GO:0004352
Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.
7 A3MUY9 (/IDA) P00367 (/IDA) P10860 (/IDA) P39633 (/IDA) P49448 (/IDA) P54385 (/IDA) Q38946 (/IDA)
Glutamate dehydrogenase [NAD(P)+] activity GO:0004353
Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
7 P00367 (/IDA) P26443 (/IDA) P49448 (/IDA) P54385 (/IDA) Q38946 (/IDA) Q43314 (/IDA) Q54KB7 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P00367 (/IPI) P26443 (/IPI) P39633 (/IPI)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
2 Q38946 (/IDA) Q43314 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q38946 (/IDA) Q43314 (/IDA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
2 P00367 (/IDA) P49448 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 Q38946 (/IDA) Q43314 (/IDA)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
2 P00367 (/IDA) P49448 (/IDA)
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
2 Q38946 (/IDA) Q43314 (/IDA)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
2 A3MUY9 (/IDA) P00367 (/IDA)
Leucine binding GO:0070728
Interacting selectively and non-covalently with 2-amino-4-methylpentanoic acid.
2 P00367 (/IDA) P49448 (/IDA)
Glutamate dehydrogenase (NAD+) activity GO:0004352
Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.
1 P50735 (/IMP)
Glutamate dehydrogenase (NAD+) activity GO:0004352
Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.
1 P26443 (/ISO)
Glutamate dehydrogenase [NAD(P)+] activity GO:0004353
Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
1 P00367 (/EXP)
Glutamate dehydrogenase [NAD(P)+] activity GO:0004353
Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
1 Q43314 (/IMP)
Glutamate dehydrogenase [NAD(P)+] activity GO:0004353
Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
1 P26443 (/ISO)
Glutamate dehydrogenase (NADP+) activity GO:0004354
Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
1 A3MWK6 (/IDA)
Glutamate dehydrogenase (NADP+) activity GO:0004354
Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
1 P54386 (/ISS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 P26443 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P10860 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P54385 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P00367 (/TAS)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
1 P26443 (/ISO)
NADP+ binding GO:0070401
Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
1 A3MWK6 (/IDA)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
1 A3MWK6 (/IDA)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
1 P26443 (/ISO)
NADH binding GO:0070404
Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
1 A3MUY9 (/IDA)
Leucine binding GO:0070728
Interacting selectively and non-covalently with 2-amino-4-methylpentanoic acid.
1 P26443 (/ISO)

There are 44 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
7 P27346 (/ISS) Q5HHC7 (/ISS) Q6GAW8 (/ISS) Q6GID0 (/ISS) Q7A1B9 (/ISS) Q7A6H8 (/ISS) Q99VD0 (/ISS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
7 P27346 (/ISS) Q5HHC7 (/ISS) Q6GAW8 (/ISS) Q6GID0 (/ISS) Q7A1B9 (/ISS) Q7A6H8 (/ISS) Q99VD0 (/ISS)
Glutamine metabolic process GO:0006541
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
5 P00366 (/ISS) P00367 (/ISS) P00368 (/ISS) P10860 (/ISS) P82264 (/ISS)
Response to food GO:0032094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.
5 Q70PJ6 (/IDA) Q70PJ7 (/IDA) Q8JG17 (/IDA) Q8JHX9 (/IDA) Q8JHY1 (/IDA)
Tricarboxylic acid metabolic process GO:0072350
The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).
5 P00366 (/ISS) P00367 (/ISS) P00368 (/ISS) P10860 (/ISS) P82264 (/ISS)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
4 A3MUY9 (/IDA) A3MWK6 (/IDA) P49448 (/IDA) P54385 (/IDA)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
4 Q33E23 (/IEP) Q38946 (/IEP) Q43314 (/IEP) Q6H3Y7 (/IEP)
Cellular response to nitrogen starvation GO:0006995
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen.
3 Q33E23 (/IEP) Q6H3Y7 (/IEP) Q852M0 (/IEP)
Glutamate catabolic process to 2-oxoglutarate GO:0019551
The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.
3 P54385 (/ISS) Q8T453 (/ISS) Q9VCN3 (/ISS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
3 A3MUY9 (/IDA) A3MWK6 (/IDA) P49448 (/IDA)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
2 A3MUY9 (/IDA) A3MWK6 (/IDA)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
2 P39633 (/IMP) P50735 (/IMP)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
2 P00367 (/IDA) P49448 (/IDA)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
2 P54386 (/ISS) Q81SY3 (/ISS)
Glutamate catabolic process GO:0006538
The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.
2 P00367 (/IDA) P49448 (/IDA)
Glutamate catabolic process GO:0006538
The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.
2 P00366 (/ISS) Q54KB7 (/ISS)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
2 Q8T453 (/IMP) Q9VCN3 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 Q8T453 (/IMP) Q9VCN3 (/IMP)
Response to alkaline pH GO:0010446
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.
2 Q33E23 (/IEP) Q6H3Y7 (/IEP)
Protein hexamerization GO:0034214
The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
2 A3MUY9 (/IDA) A3MWK6 (/IDA)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 Q38946 (/IEP) Q43314 (/IEP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
2 P39633 (/IMP) P50735 (/IMP)
Response to nitrogen compound GO:1901698
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.
2 Q33E23 (/IEP) Q852M0 (/IEP)
NADH oxidation GO:0006116
A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD.
1 P54385 (/IDA)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
1 Q60A41 (/ISS)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
1 P26443 (/ISO)
Glutamate catabolic process GO:0006538
The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.
1 P26443 (/ISO)
Glutamate catabolic process GO:0006538
The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.
1 P10860 (/TAS)
Glutamine metabolic process GO:0006541
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
1 P26443 (/IMP)
Nitrogen compound metabolic process GO:0006807
The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
1 Q43314 (/IMP)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 P00367 (/TAS)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
1 P10860 (/IEP)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
1 P00367 (/TAS)
Glutamine family amino acid metabolic process GO:0009064
The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
1 Q5LSM4 (/ISS)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
1 Q33E23 (/IEP)
Response to absence of light GO:0009646
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli.
1 Q43314 (/IEP)
Response to aluminum ion GO:0010044
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus.
1 P10860 (/IDA)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 P10860 (/IEP)
Substantia nigra development GO:0021762
The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).
1 P00367 (/IEP)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 P26443 (/IGI)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 P00367 (/IMP)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 P26443 (/ISO)
Regulation of nitrogen compound metabolic process GO:0051171
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
1 Q9S7A0 (/IEP)
Tricarboxylic acid metabolic process GO:0072350
The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).
1 P26443 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
11 E9KL48 (/IDA) P00367 (/IDA) P10860 (/IDA) P26443 (/IDA) P49448 (/IDA) P54385 (/IDA) Q38946 (/IDA) Q43314 (/IDA) Q8T453 (/IDA) Q9S7A0 (/IDA)
(1 more)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 P54385 (/ISS) Q8T453 (/ISS) Q9VCN3 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P00367 (/IDA) P54385 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P00366 (/ISS) Q54KB7 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P26443 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P54386 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P26443 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P26443 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P00366 (/ISS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P26443 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P00367 (/TAS)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
1 Q38946 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P54385 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q54KB7 (/IDA)