View in Gene3D

CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 291695: 1,5-anhydro-D-fructose reductase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming). [EC: 1.1.1.292]
1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + NADPH.
  • Present in some but not all Rhizobium species.
  • Differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263).
  • In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro- D-mannitol, can be further metabolized to D-mannose.
  • Also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone.
  • Does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones.
 12 F7X1U9 F7X1U9 H0G9G6 H0G9G6 I3XEM5 I3XEM5 M4MYQ2 M4MYQ2 Q2I8V6 Q2I8V6
(2 more...)
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase. [EC: 1.1.1.312]
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo- 2H-pyran-4,6-dicarboxylate + NADPH.
  • The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD(+) can replace NADP(+), but with lower affinity.
  • The enzyme was initially believed to act on 4-carboxy-2-hydroxy- cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy- cis,cis-muconate.
  • However, later studies showed that the substrate is the hemiacetal form, and the product is 2-oxo-2H-pyran-4,6-dicarboxylate.
  • Formerly EC 1.2.1.45.
 4 G2IQQ2 G2IQQ2 Q9KWL3 Q9KWL3
Glucose-fructose oxidoreductase. [EC: 1.1.99.28]
D-glucose + D-fructose = D-gluconolactone + D-glucitol.
  • D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities.
  • The ketose substrate must be in the open-chain form.
  • The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form.
  • Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates.
  • The enzyme from Zymomonas mobilis contains tightly bound NADP(+).
 2 A0A1L3L855 A0A1L3L855