The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"NAD(P)-binding Rossmann-like Domain
".
FunFam 291202: Bifunctional methylenetetrahydrofolate dehydrogena...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Methenyltetrahydrofolate cyclohydrolase activity GO:0004477
Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
|
2 | P13995 (/ISS) Q04448 (/ISS) |
|
Methenyltetrahydrofolate cyclohydrolase activity GO:0004477
Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
|
2 | P13995 (/TAS) Q9H903 (/TAS) |
|
Methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0004487
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
|
2 | P13995 (/TAS) Q9H903 (/TAS) |
|
Methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.
|
2 | D3ZUA0 (/IDA) P13995 (/IDA) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | P13995 (/IDA) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | P18155 (/ISO) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | Q04448 (/ISS) |
|
Methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0004487
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
|
1 | P13995 (/IDA) |
|
Methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0004487
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
|
1 | P18155 (/ISO) |
|
Methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0004487
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
|
1 | Q04448 (/ISS) |
|
Methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.
|
1 | P18155 (/ISO) |
|
Methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.
|
1 | Q04448 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | B2R7W0 (/IPI) |
|
Phosphate ion binding GO:0042301
Interacting selectively and non-covalently with phosphate.
|
1 | P13995 (/IDA) |
|
Phosphate ion binding GO:0042301
Interacting selectively and non-covalently with phosphate.
|
1 | P18155 (/ISO) |
|
Phosphate ion binding GO:0042301
Interacting selectively and non-covalently with phosphate.
|
1 | Q04448 (/ISS) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Folic acid metabolic process GO:0046655
The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
2 | P13995 (/TAS) Q9H903 (/TAS) |
|
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
|
1 | Q04448 (/ISS) |
|
10-formyltetrahydrofolate metabolic process GO:0009256
The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.
|
1 | D3ZUA0 (/IDA) |
|
10-formyltetrahydrofolate metabolic process GO:0009256
The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.
|
1 | Q04448 (/ISS) |
|
Tetrahydrofolate interconversion GO:0035999
The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.
|
1 | D3ZUA0 (/IDA) |
|
Tetrahydrofolate metabolic process GO:0046653
The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
|
1 | P13995 (/IDA) |
|
Tetrahydrofolate metabolic process GO:0046653
The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
|
1 | P18155 (/ISO) |
|
Tetrahydrofolate metabolic process GO:0046653
The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
|
1 | Q04448 (/ISS) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P13995 (/ISS) Q04448 (/ISS) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
2 | P13995 (/TAS) Q9H903 (/TAS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P13995 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P18155 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P18155 (/IDA) |
|
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
1 | D3ZUA0 (/IDA) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | D3ZUA0 (/IDA) |