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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291202: Bifunctional methylenetetrahydrofolate dehydrogena...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Methylenetetrahydrofolate dehydrogenase (NADP(+)). [EC: 1.5.1.5]
5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.
    		 303 A0A014MGG3 A0A059WZT9 A0A068D1P7 A0A074T3X3 A0A075WUL4 A0A078KHH6 A0A083WPH1 A0A084EJR2 A0A089P6E0 A0A090DYM4
    (293 more...)
    Methenyltetrahydrofolate cyclohydrolase. [EC: 3.5.4.9]
    5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
      		 297 A0A014MGG3 A0A059WZT9 A0A061HZ57 A0A061INB2 A0A061IPZ9 A0A068D1P7 A0A075WUL4 A0A078KHH6 A0A083WPH1 A0A084EJR2
      (287 more...)
      Methylenetetrahydrofolate dehydrogenase (NAD(+)). [EC: 1.5.1.15]
      5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
        		 11 A0A0B4KFE5 D3YZG8 D3ZUA0 E0VDT6 F6ZFR0 P13995 P18155 Q04448 Q0P5C2 Q5ZKA5
        (1 more...)
        Formate--tetrahydrofolate ligase. [EC: 6.3.4.3]
        ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
        • In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.
        		 1 A0A0B4KFE5