View in Gene3D

CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 291076: NADP-dependent alcohol dehydrogenase C

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.2]
An alcohol + NADP(+) = an aldehyde + NADPH.
  • Some members of this group oxidize only primary alcohols; others act also on secondary alcohols.
  • May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55.
  • Re-specific with respect to NADPH.
 1124 A0A009I5I3 A0A009I5I3 A0A009JLV1 A0A009JLV1 A0A009PDL8 A0A009PDL8 A0A009TBJ5 A0A009TBJ5 A0A024GYM7 A0A024GYM7
(1114 more...)
Alcohol dehydrogenase. [EC: 1.1.1.1]
(1) An alcohol + NAD(+) = an aldehyde or ketone + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
  • Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.
  • The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
 588 A0A017HK22 A0A017HK22 A0A023YTT0 A0A023YTT0 A0A024KA49 A0A024KA49 A0A024KTQ2 A0A024KTQ2 A0A025BYP5 A0A025BYP5
(578 more...)
Mannitol dehydrogenase. [EC: 1.1.1.255]
D-mannitol + NAD(+) = D-mannose + NADH.
  • The enzyme from Apium graveolens (celery) oxidizes alditols with a minimum requirement of 2R chirality at the carbon adjacent to the primary carbon undergoing the oxidation.
  • The enzyme is specific for NAD(+) and does not use NADP(+).
 166 A0A031I1Z1 A0A031I1Z1 A0A063BDN0 A0A063BDN0 A0A099L8J4 A0A099L8J4 A0A0B8ZXB0 A0A0B8ZXB0 A0A0C1YZH9 A0A0C1YZH9
(156 more...)
Cinnamyl-alcohol dehydrogenase. [EC: 1.1.1.195]
Cinnamyl alcohol + NADP(+) = cinnamaldehyde + NADPH.
  • Acts on coniferyl alcohol, sinapyl alcohol, 4-coumaryl alcohol and cinnamyl alcohol (cf. EC 1.1.1.194).
 36 A0A090PIT9 A0A090PIT9 A0A090PVY0 A0A090PVY0 A0A090QHB5 A0A090QHB5 A0A090WFC5 A0A090WFC5 A0A0K2X2F8 A0A0K2X2F8
(26 more...)
DNA-directed RNA polymerase. [EC: 2.7.7.6]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
  • Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
  • Can initiate a chain de novo.
  • In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized.
  • See also EC 2.7.7.19 and EC 2.7.7.48.
 14 A0A093Y141 A0A093Y141 A0A093YKI0 A0A093YKI0 A0A094A7I5 A0A094A7I5 A0A094AJX3 A0A094AJX3 A0A094CUA4 A0A094CUA4
(4 more...)
Coniferyl-alcohol dehydrogenase. [EC: 1.1.1.194]
Coniferyl alcohol + NADP(+) = coniferyl aldehyde + NADPH.
  • Specific for coniferyl alcohol; does not act on cinnamyl alcohol, 4-coumaryl alcohol or sinapyl alcohol.
 4 A0A179RCB9 A0A179RCB9 Q88K65 Q88K65
Isopropanol dehydrogenase (NADP(+)). [EC: 1.1.1.80]
Propan-2-ol + NADP(+) = acetone + NADPH.
  • Also acts on other short-chain secondary alcohols and, slowly, on primary alcohols.
 2 A0A084G3U4 A0A084G3U4
Geraniol dehydrogenase (NADP(+)). [EC: 1.1.1.183]
Geraniol + NADP(+) = geranial + NADPH.
  • Also acts, more slowly on farnesol but not on nerol.
  • The enzyme produces a mixture known as citral, which includes geranial and neral.
  • It is still not known whether neral is produced directly by the enzyme, or by isomerization of geranial.
 2 A0A084G0S1 A0A084G0S1
8-hydroxygeraniol dehydrogenase. [EC: 1.1.1.324]
(6E)-8-hydroxygeraniol + 2 NADP(+) = (6E)-8-oxogeranial + 2 NADPH.
  • The enzyme catalyzes the oxidation of (6E)-8-hydroxygeraniol to (6E)- 8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8- oxogeraniol.
  • Also acts on geraniol, nerol and citronellol.
  • May be identical to EC 1.1.1.183.
  • The recommended numbering of geraniol gives 8-hydroxygeraniol as the substrate rather than 10-hydroxygeraniol.
 2 A0A084G0S1 A0A084G0S1