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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 290699: Carbonyl reductase [NADPH] 1

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Carbonyl reductase (NADPH). [EC: 1.1.1.184]
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
  • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
  • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
 64 A0A061I2B6 A0A074TEU1 A0A086KA98 A0A086KD39 A0A086M1P4 A0A0B2NQS3 A0A0B2NVZ2 A0A0B2P5V2 A0A0B2P5Y7 A0A0B2PAC8
(54 more...)
Prostaglandin-E(2) 9-reductase. [EC: 1.1.1.189]
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
  • Reduces prostaglandin E(2) to prostaglandin F(2)-alpha.
  • A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds.
  • May be identical with EC 1.1.1.197.
 25 A0A0B2PAC8 A0A0B2RF98 A0A0B2RJ58 B2RXY7 B7QLU2 B9RA50 B9RDN2 B9RDN3 B9RDN4 B9RDN5
(15 more...)
15-hydroxyprostaglandin dehydrogenase (NADP(+)). [EC: 1.1.1.197]
(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)- 11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.
  • Acts on prostaglandins E(2), F(2)-alpha and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.141 and EC 1.1.1.196).
  • May be identical with EC 1.1.1.189.
 17 A0A0B2PAC8 A0A0B2RF98 A0A0B2RJ58 B2RXY7 G3QKD3 H2QKZ8 I1JF07 I1KLU8 I3RWJ1 P16152
(7 more...)
(+)-neomenthol dehydrogenase. [EC: 1.1.1.208]
(+)-neomenthol + NADP(+) = (-)-menthone + NADPH.
  • Acts on a number of other cyclohexanols and cyclohexenols.
  • Not identical with EC 1.1.1.207.
 3 B2X050 Q06ZW2 Q9M2E2
Salutaridine reductase (NADPH). [EC: 1.1.1.248]
Salutaridinol + NADP(+) = salutaridine + NADPH.
  • Catalyzes the reversible reduction of salutaridine to salutaridinol, which is a direct precursor of morphinan alkaloids in the poppy plant.
 2 A4UHT7 Q071N0
(-)-isopiperitenone reductase. [EC: 1.3.1.82]
(+)-cis-isopulegone + NADP(+) = (-)-isopiperitenone + NADPH.
  • The reaction occurs in the opposite direction to that shown above.
  • Participates in the menthol-biosynthesis pathway of Mentha plants.
  • (+)-pulegone, (+)-cis-isopulegone and (-)-menthone are not substrates.
  • Has a preference for NADPH as the reductant, with NADH being a poor substitute.
  • Highly regioselective for the reduction of the endocyclic 1,2-double bond, and is stereoselective, producing only the 1R-configured product.
 1 Q6WAU1
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase. [EC: 1.1.1.53]
Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH.
  • The 3-alpha-hydroxy group or 20-beta-hydroxy group of pregnane and androstane steroids can act as donor.
 1 A0A191Y209