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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 290680: Probable trans-2-enoyl-CoA reductase, mitochondria...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Trans-2-enoyl-CoA reductase (NADPH). [EC: 1.3.1.38]
Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
  • Not identical with EC 1.3.1.37 (cf. EC 1.3.1.8).
 78 A0A0B2REF5 A0A0B2REF5 A0A0F4Z493 A0A0F4Z493 A0A0J9RC41 A0A0J9RC41 A0A0L8VV79 A0A0L8VV79 A0A178VNZ5 A0A178VNZ5
(68 more...)
Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific). [EC: 1.3.1.10]
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
  • One of the activities of EC 2.3.1.86, an enzyme found in yeasts (Ascomycota and the Basidiomycota).
  • Catalyzes the reduction of enoyl-acyl-[acyl-carrier protein] derivatives of carbon chain length from 4 to 16.
  • The yeast enzyme is Si-specific with respect to NADP(+).
  • Cf. EC 1.3.1.39 and EC 1.3.1.104 which describes enzymes whose stereo-specificity toward NADPH is not known.
  • See also EC 1.3.1.9.
 18 A0A0L8VV79 A0A0L8VV79 A6ZKX2 A6ZKX2 B3LNB7 B3LNB7 B9WCZ9 B9WCZ9 C8Z420 C8Z420
(8 more...)
DNA helicase. [EC: 3.6.4.12]
ATP + H(2)O = ADP + phosphate.
  • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
  • Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15).
  • Some helicases unwind DNA as well as RNA (4,9).
  • May be identical with EC 3.6.4.13 (RNA helicase).
 2 A0A0N4W949 A0A0N4W949
NAD(P)H dehydrogenase (quinone). [EC: 1.6.5.2]
NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
  • The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone.
  • The animal, but not the plant, form of the enzyme is inhibited by dicoumarol.
  • Formerly EC 1.6.99.2.
 2 Q8NJJ9 Q8NJJ9