The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 290458: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, c...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
1-deoxy-D-xylulose-5-phosphate reductoisomerase. [EC: 1.1.1.267]
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
  • The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
  • The mechanism has been shown to be a retroaldol/aldol reaction.
18174 A0A009FCD1 A0A009FCD1 A0A009GCU6 A0A009GCU6 A0A009H3K9 A0A009H3K9 A0A009H992 A0A009H992 A0A009HIH9 A0A009HIH9
(18164 more...)
1-deoxy-D-xylulose-5-phosphate synthase. [EC: 2.2.1.7]
Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO(2).
  • The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
  • Formerly EC 4.1.3.37.
8 B2KK84 B2KK84 B2KK85 B2KK85 B2KK86 B2KK86 B2KK87 B2KK87
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase. [EC: 2.7.7.60]
CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
  • ATP or UTP can replace CTP, but both are less effective.
  • GTP and TTP are not substrates.
  • Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
2 I3V642 I3V642