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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 290185: Oxidoreductase, short-chain dehydrogenase/reductas...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Carbonyl reductase (NADPH). [EC: 1.1.1.184]
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
  • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
  • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
 20 A0A0E2YZU9 A0A0T7CZA4 A0A0T7DGB6 A0A0T7DS75 A0A0T7E9J4 A0A0T7ERW5 A0A0W0SVZ4 A0A0W0VE88 A0A0W0VKS8 A0A0W0VU06
(10 more...)
3-oxoacyl-[acyl-carrier-protein] reductase. [EC: 1.1.1.100]
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
  • Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.
 12 A3LVX4 K0KBX2 K0KHD1 K0KIB1 K0KJX2 K0KK09 K0KL12 K0KMG0 K0KTC7 K0KTZ7
(2 more...)
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase. [EC: 1.3.1.28]
2,3-dihydro-2,3-dihydroxybenzoate + NAD(+) = 2,3-dihydroxybenzoate + NADH.
  • Formerly EC 1.1.1.109.
 2 D5BN97 Q3M611
All-trans-retinol dehydrogenase (NAD(+)). [EC: 1.1.1.105]
All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) = all- trans-retinal-[cellular-retinol-binding-protein] + NADH.
  • The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors.
  • Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
  • No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315).
  • Also active with 3-alpha-hydroxysteroids.
 1 A0A098GHG9