The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 289886: Fermentative D-lactate dehydrogenase, NAD-dependen...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
D-lactate dehydrogenase activity GO:0008720
Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate.
3 Q54UF7 (/ISS) Q8EI78 (/ISS) Q9KMX4 (/ISS)
Formate dehydrogenase (NAD+) activity GO:0008863
Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH.
3 D6CJK0 (/IDA) O13437 (/IDA) Q08911 (/IDA)
Formate dehydrogenase (NAD+) activity GO:0008863
Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH.
2 P0CF35 (/IGI) Q08911 (/IGI)
Formate dehydrogenase (NAD+) activity GO:0008863
Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH.
2 P0CF35 (/ISS) Q08911 (/ISS)
D-lactate dehydrogenase activity GO:0008720
Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate.
1 P52643 (/IDA)
Formate dehydrogenase (NAD+) activity GO:0008863
Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH.
1 O13437 (/IMP)
Formate dehydrogenase (NAD+) activity GO:0008863
Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH.
1 Q03134 (/RCA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 O13437 (/IDA)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
1 O13437 (/IDA)
NADH binding GO:0070404
Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
1 P52643 (/IDA)
Phenyllactate dehydrogenase activity GO:0097256
Catalysis of the oxidation of phenyllactate to produce phenylpyruvate.
1 G9EZR6 (/IDA)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fermentation GO:0006113
The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP).
2 Q8EI78 (/ISS) Q9KMX4 (/ISS)
Formate catabolic process GO:0042183
The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.
2 P0CF35 (/IGI) Q08911 (/IGI)
Acetate metabolic process GO:0006083
The chemical reactions and pathways involving acetate, the anion of acetic acid.
1 Q03134 (/IEP)
Glycine catabolic process GO:0006546
The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid.
1 Q59QN6 (/NAS)
L-phenylalanine catabolic process GO:0006559
The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
1 G9EZR6 (/IDA)
NADH metabolic process GO:0006734
The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
1 O13437 (/IMP)
NADH regeneration GO:0006735
A metabolic process that generates a pool of NADH by the reduction of NAD+.
1 O13437 (/IDA)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 P52643 (/IEP)
Methanol oxidation GO:0015946
The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M.
1 O13437 (/IMP)
Mixed acid fermentation GO:0019664
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP.
1 P52643 (/IDA)
Mixed acid fermentation GO:0019664
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP.
1 P52643 (/IMP)
Methylamine metabolic process GO:0030416
The chemical reactions and pathways involving methylamine (CH3NH2).
1 O13437 (/IMP)
Oxalate metabolic process GO:0033609
The chemical reactions and pathways involving oxalate, the organic acid ethanedioate.
1 Q03134 (/RCA)
Formate catabolic process GO:0042183
The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.
1 O13437 (/IDA)
Choline catabolic process GO:0042426
The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
1 O13437 (/IMP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q9S7E4 (/IEP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P52643 (/IDA) Q08911 (/IDA) Q9P7P8 (/IDA) Q9P7Q1 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
2 Q03134 (/IDA) Q4WDJ0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9P7P8 (/IDA) Q9P7Q1 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O13437 (/ISS) P0CF35 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q03134 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9S7E4 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q9S7E4 (/IDA)
Thylakoid GO:0009579
A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
1 Q9S7E4 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q54UF7 (/IDA)
Biofilm matrix GO:0097311
A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria.
1 Q59QN6 (/IDA)