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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 289861: UDP-N-acetylglucosamine 4,6-dehydratase (inverting...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UDP-glucose 4-epimerase. [EC: 5.1.3.2]
UDP-alpha-D-glucose = UDP-alpha-D-galactose.
  • Also acts on UDP-2-deoxyglucose.
 164 A0A078S4L0 A0A078S4L0 A0A087RM31 A0A087RM31 A0A087S2H5 A0A087S2H5 A0A0B7I3N7 A0A0B7I3N7 A0A0F1B0T2 A0A0F1B0T2
(154 more...)
UDP-N-acetylglucosamine 4,6-dehydratase (inverting). [EC: 4.2.1.115]
UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L- arabino-hex-4-ulose + H(2)O.
  • The first enzyme in the biosynthetic pathway of pseudaminic acid, a sialic-acid-like sugar that is unique to bacteria and is used by Helicobacter pylori to modify its flagellin.
  • Plays a critical role in H.pylori's pathogenesis, being involved in the synthesis of both functional flagella and lipopolysaccharides.
  • Completely inhibited by UDP-alpha-D-galactose.
  • The reaction results in the chirality of the C-5 atom being inverted.
  • It is thought that Lys-133 acts sequentially as a catalytic acid, protonating the C-6 hydroxy group and as a catalytic base, abstracting the C-5 proton, resulting in the elimination of water.
 126 A0A072NM99 A0A072NM99 A0A072P4C1 A0A072P4C1 A0A075GY07 A0A075GY07 A0A075GZA6 A0A075GZA6 A0A075GZD7 A0A075GZD7
(116 more...)
UDP-glucose 4,6-dehydratase. [EC: 4.2.1.76]
UDP-alpha-D-glucose = UDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O.
    		 2 Q11RE8 Q11RE8