The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 288420: Bifunctional glyoxylate/hydroxypyruvate reductase ...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glyoxylate reductase (NADP(+)). [EC: 1.1.1.79]
Glycolate + NADP(+) = glyoxylate + NADPH.
  • Also reduces hydroxypyruvate to glycerate.
  • Has some affinity for NAD(+).
538 A0A017I372 A0A023V5U4 A0A024KQX6 A0A026RYP5 A0A026UU81 A0A027U640 A0A028AUM8 A0A028E258 A0A029HHH8 A0A029IIZ0
(528 more...)
Hydroxypyruvate reductase. [EC: 1.1.1.81]
D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.
    536 A0A017I372 A0A023V5U4 A0A024KQX6 A0A026RYP5 A0A026UU81 A0A027U640 A0A028AUM8 A0A028E258 A0A029HHH8 A0A029IIZ0
    (526 more...)
    Gluconate 2-dehydrogenase. [EC: 1.1.1.215]
    D-gluconate + NADP(+) = 2-dehydro-D-gluconate + NADPH.
    • Also acts on L-idonate, D-galactonate and D-xylonate.
    100 A0A026UU81 A0A027U640 A0A028AUM8 A0A028E258 A0A029HHH8 A0A029IIZ0 A0A029PP65 A0A037YLL4 A0A070DI53 A0A070FKU7
    (90 more...)