The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 288364: Short-chain dehydrogenase reductase 3a

There are 20 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase. [EC: 1.1.1.53]
Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH.
  • The 3-alpha-hydroxy group or 20-beta-hydroxy group of pregnane and androstane steroids can act as donor.
480 A0A024H602 A0A024H602 A0A045JKA8 A0A045JKA8 A0A049DPX5 A0A049DPX5 A0A049ED58 A0A049ED58 A0A081HXD2 A0A081HXD2
(470 more...)
3-oxoacyl-[acyl-carrier-protein] reductase. [EC: 1.1.1.100]
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
  • Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.
224 A0A011SGH8 A0A011SGH8 A0A024KJA0 A0A024KJA0 A0A031JIS1 A0A031JIS1 A0A081R9Z8 A0A081R9Z8 A0A081RBZ9 A0A081RBZ9
(214 more...)
Glucose 1-dehydrogenase (NAD(P)(+)). [EC: 1.1.1.47]
D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H.
  • This enzyme has similar activity with either NAD(+) or NADP(+).
  • Cf. EC 1.1.1.118 and EC 1.1.1.119.
176 A0A023P8I8 A0A023P8I8 A0A085C5B6 A0A085C5B6 A0A0A7U1X8 A0A0A7U1X8 A0A0B5REA1 A0A0B5REA1 A0A0C1PT40 A0A0C1PT40
(166 more...)
Cyclopentanol dehydrogenase. [EC: 1.1.1.163]
Cyclopentanol + NAD(+) = cyclopentanone + NADH.
  • 4-methylcyclohexanol and cyclohexanol can also act as substrates.
82 A0A070ADV2 A0A070ADV2 A0A090FNB7 A0A090FNB7 A0A0B0I341 A0A0B0I341 A0A0D6HUZ8 A0A0D6HUZ8 A0A0D6J3X7 A0A0D6J3X7
(72 more...)
3(or 17)-beta-hydroxysteroid dehydrogenase. [EC: 1.1.1.51]
Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H.
  • Also acts on other 3-beta- or 17-beta-hydroxysteroids (cf. EC 1.1.1.209).
70 A0A024HKT7 A0A024HKT7 A0A081N820 A0A081N820 A0A088TQ85 A0A088TQ85 A0A0A1EFG4 A0A0A1EFG4 A0A0C1C4I0 A0A0C1C4I0
(60 more...)
Xanthoxin dehydrogenase. [EC: 1.1.1.288]
Xanthoxin + NAD(+) = abscisic aldehyde + NADH.
  • NADP(+) cannot replace NAD(+) and short-chain alcohols such as ethanol, isopropanol, butanol and cyclohexanol cannot replace xanthoxin as substrate.
  • Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.2.3.14, EC 1.13.11.51 and EC 1.14.13.93.
36 A0A0B2NUR2 A0A0B2NUR2 A0A0B2NYQ1 A0A0B2NYQ1 A0A0B2PWJ5 A0A0B2PWJ5 A0A0B2Q126 A0A0B2Q126 A0A0B2Q1Z9 A0A0B2Q1Z9
(26 more...)
Momilactone-A synthase. [EC: 1.1.1.295]
3-beta-hydroxy-9-beta-pimara-7,15-diene-19,6-beta-olide + NAD(P)(+) = momilactone A + NAD(P)H.
  • The rice phytoalexin momilactone A is a diterpenoid secondary metabolite that is involved in the defense mechanism of the plant.
  • Momilactone A is produced in response to attack by a pathogen through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation.
  • The enzyme, which catalyzes the last step in the biosynthesis of momilactone A, can use both NAD(+) and NADP(+) but activity is higher with NAD(+).
28 A0A0B2NYG7 A0A0B2NYG7 A0A0B2P3E4 A0A0B2P3E4 A0A0B2PI21 A0A0B2PI21 A0A0B2PUW1 A0A0B2PUW1 A0A0B2QI61 A0A0B2QI61
(18 more...)
Dihydroanticapsin 7-dehydrogenase. [EC: 1.1.1.385]
L-dihydroanticapsin + NAD(+) = L-anticapsin + NADH.
  • The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin.
16 A0A085C5B6 A0A085C5B6 A0A0A0U2D2 A0A0A0U2D2 A0A1A5VMV5 A0A1A5VMV5 A0A1D8FNE5 A0A1D8FNE5 E1USX8 E1USX8
(6 more...)
Secoisolariciresinol dehydrogenase. [EC: 1.1.1.331]
(-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 NADH.
  • Isolated from the plants Forsythia intermedia and Podophyllum peltatum.
  • An intermediate lactol is detected in vitro.
8 A0A0M4J2R3 A0A0M4J2R3 Q1ZZ69 Q1ZZ69 Q94KL7 Q94KL7 Q94KL8 Q94KL8
Cyclohexanol dehydrogenase. [EC: 1.1.1.245]
Cyclohexanol + NAD(+) = cyclohexanone + NADH.
  • Also oxidizes some other alicyclic alcohols and diols.
8 A0A0H3C5H2 A0A0H3C5H2 Q0K3M6 Q0K3M6 Q9ABI1 Q9ABI1 R7XIH0 R7XIH0
Alcohol dehydrogenase. [EC: 1.1.1.1]
(1) An alcohol + NAD(+) = an aldehyde or ketone + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
  • Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.
  • The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
6 I3XL71 I3XL71 Q8VLS3 Q8VLS3 U5PZ79 U5PZ79
Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific). [EC: 1.3.1.10]
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
  • One of the activities of EC 2.3.1.86, an enzyme found in yeasts (Ascomycota and the Basidiomycota).
  • Catalyzes the reduction of enoyl-acyl-[acyl-carrier protein] derivatives of carbon chain length from 4 to 16.
  • The yeast enzyme is Si-specific with respect to NADP(+).
  • Cf. EC 1.3.1.39 and EC 1.3.1.104 which describes enzymes whose stereo-specificity toward NADPH is not known.
  • See also EC 1.3.1.9.
4 A0A059E649 A0A059E649 A0A160U0M7 A0A160U0M7
4-formylbenzenesulfonate dehydrogenase. [EC: 1.2.1.62]
4-formylbenzenesulfonate + NAD(+) + H(2)O = 4-sulfobenzoate + NADH.
  • Involved in the toluene-4-sulfonate degradation pathway.
4 A0A0J6Y6P1 A0A0J6Y6P1 A0A0J6Z7R6 A0A0J6Z7R6
3-hydroxybutyrate dehydrogenase. [EC: 1.1.1.30]
(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.
  • Also oxidizes other 3-hydroxymonocarboxylic acids.
4 D8GUP3 D8GUP3 U5RTP1 U5RTP1
(S)-1-phenylethanol dehydrogenase. [EC: 1.1.1.311]
(S)-1-phenylethanol + NAD(+) = acetophenone + NADH.
  • The enzyme is involved in degradation of ethylbenzene.
2 A0A1A6AS12 A0A1A6AS12
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase. [EC: 1.3.1.28]
2,3-dihydro-2,3-dihydroxybenzoate + NAD(+) = 2,3-dihydroxybenzoate + NADH.
  • Formerly EC 1.1.1.109.
2 B9RN76 B9RN76
Zerumbone synthase. [EC: 1.1.1.326]
10-hydroxy-alpha-humulene + NAD(+) = zerumbone + NADH.
  • The enzyme was cloned from shampoo ginger, Zingiber zerumbet.
2 F1SWA0 F1SWA0
Transferred entry: 1.1.1.303 and 1.1.1.304. [EC: 1.1.1.5]
    2 B9SDK5 B9SDK5
    Isopiperitenol dehydrogenase. [EC: 1.1.1.223]
    (-)-trans-isopiperitenol + NAD(+) = (-)-isopiperitenone + NADH.
    • Acts on (-)-trans-isopiperitenol, (+)-trans-piperitenol and (+)- trans-pulegol.
    • Involved in the biosynthesis of menthol and related monoterpenes in peppermint (Mentha piperita) leaves.
    2 Q5C9I9 Q5C9I9
    Carveol dehydrogenase. [EC: 1.1.1.243]
    (-)-trans-carveol + NADP(+) = (-)-carvone + NADPH.
      2 Q5C9I9 Q5C9I9