The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 287348: NAD-dependent glyceraldehyde-3-phosphate dehydroge...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Erythrose-4-phosphate dehydrogenase. [EC: 1.2.1.72]
D-erythrose 4-phosphate + NAD(+) + H(2)O = 4-phosphoerythronate + NADH.
  • Was originally thought to be an EC 1.2.1.12, but this has since been disproved, as glyceraldehyde 3-phosphate is not a substrate.
  • Forms part of the pyridoxal-5'-phosphate coenzyme biosynthesis pathway in Escherichia coli, along with EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5.
2480 A0A010Q876 A0A010Q876 A0A014NK41 A0A014NK41 A0A017I8X5 A0A017I8X5 A0A022PFP6 A0A022PFP6 A0A023E4F7 A0A023E4F7
(2470 more...)
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). [EC: 1.2.1.12]
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
  • Also acts very slowly on D-glyceraldehyde and some other aldehydes.
  • Thiols can replace phosphate.
158 A0A059ZLL8 A0A059ZLL8 A0A066TJN7 A0A066TJN7 A0A081NIU5 A0A081NIU5 A0A094IX56 A0A094IX56 A0A094L1I7 A0A094L1I7
(148 more...)
Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)). [EC: 1.2.1.9]
D-glyceraldehyde 3-phosphate + NADP(+) + H(2)O = 3-phospho-D-glycerate + NADPH.
    2 H8WE48 H8WE48
    Phosphoglycerate kinase. [EC: 2.7.2.3]
    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.
      2 A0A077ZMJ5 A0A077ZMJ5