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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 285506: Similar to dTDP-4-dehydrorhamnose reductase

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UDP-glucose 4,6-dehydratase. [EC: 4.2.1.76]
UDP-alpha-D-glucose = UDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O.
    		 32 A0A0B2Q3J0 A0A0B2Q3J0 A0A0B2QDK9 A0A0B2QDK9 A0A0B2QEW4 A0A0B2QEW4 A0A0B2QI97 A0A0B2QI97 A0A0B2R6D0 A0A0B2R6D0
    (22 more...)
    DTDP-4-dehydrorhamnose reductase. [EC: 1.1.1.133]
    dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + NADPH.
    • In the reverse direction, reduction on the 4-position of the hexose moiety takes place only while the substrate is bound to another enzyme that catalyzes epimerization at C-3 and C-5; the complex has been referred to as dTDP-L-rhamnose synthase.
    		 8 A0A0P4U6I8 A0A0P4U6I8 B0EKL2 B0EKL2 M2X3X9 M2X3X9 Q9LQ04 Q9LQ04
    UDP-glucuronate 5'-epimerase. [EC: 5.1.3.12]
    UDP-glucuronate = UDP-L-iduronate.
      		 2 B0EQA0 B0EQA0
      Alcohol-forming fatty acyl-CoA reductase. [EC: 1.2.1.84]
      A long-chain acyl-CoA + 2 NADPH = CoA + a long-chain alcohol + 2 NADP(+).
      • The enzyme has been characterized from the plant Simmondsia chinensis (jojoba).
      • The alcohol is formed by a four-electron reduction of fatty acyl-CoA.
      • Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released.
      • The recombinant enzyme was shown to accept saturated and mono- unsaturated fatty acyl-CoAs of 16 to 22 carbons.
      		 2 M8CJ64 M8CJ64
      DTDP-4-dehydrorhamnose 3,5-epimerase. [EC: 5.1.3.13]
      dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose.
      • Occurs in a complex with EC 1.1.1.133.
      		 2 Q9LQ04 Q9LQ04
      DTDP-glucose 4,6-dehydratase. [EC: 4.2.1.46]
      dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O.
        		 2 B9SZ19 B9SZ19