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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 285086: Hydroxysteroid dehydrogenase like 2

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glucose 1-dehydrogenase (NAD(P)(+)). [EC: 1.1.1.47]
D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H.
  • This enzyme has similar activity with either NAD(+) or NADP(+).
  • Cf. EC 1.1.1.118 and EC 1.1.1.119.
 14 A0A161MBQ9 A0A161MBQ9 A0A165SG41 A0A165SG41 A0A165VGQ2 A0A165VGQ2 A0A165YI32 A0A165YI32 A0A166F047 A0A166F047
(4 more...)
3-oxoacyl-[acyl-carrier-protein] reductase. [EC: 1.1.1.100]
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
  • Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.
 4 G0QK57 G0QK57 Q2RUT8 Q2RUT8
Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific). [EC: 1.3.1.10]
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
  • One of the activities of EC 2.3.1.86, an enzyme found in yeasts (Ascomycota and the Basidiomycota).
  • Catalyzes the reduction of enoyl-acyl-[acyl-carrier protein] derivatives of carbon chain length from 4 to 16.
  • The yeast enzyme is Si-specific with respect to NADP(+).
  • Cf. EC 1.3.1.39 and EC 1.3.1.104 which describes enzymes whose stereo-specificity toward NADPH is not known.
  • See also EC 1.3.1.9.
 4 A0A0M6Y8H1 A0A0M6Y8H1 U7FT70 U7FT70
L-xylulose reductase. [EC: 1.1.1.10]
Xylitol + NADP(+) = L-xylulose + NADPH.
    		 2 B7PKM5 B7PKM5
    Propanoyl-CoA C-acyltransferase. [EC: 2.3.1.176]
    3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl- CoA.
    • Also acts on dihydroxy-5-beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives.
    • Catalyzes the penultimate step in the formation of bile acids.
    • The bile acid moiety is transferred from the acyl-CoA thioester (RCO- SCoA) to either glycine or taurine (NH(2)R') by EC 2.3.1.65.
    • Formerly EC 2.3.1.154.
    		 2 B7PKM5 B7PKM5