The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 284895: Carbonyl reductase family member 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity GO:0047025
Catalysis of the reaction: NAD+ + OH-acyl-
6 A4IFA7 (/ISS) Q68ER2 (/ISS) Q6NUE2 (/ISS) Q6P0H7 (/ISS) Q7TS56 (/ISS) Q91VT4 (/ISS)
NADPH dehydrogenase (quinone) activity GO:0008753
Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol.
3 Q7TS56 (/ISS) Q8N4T8 (/ISS) Q91VT4 (/ISS)
Quinone binding GO:0048038
Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.
3 Q7TS56 (/ISS) Q8N4T8 (/ISS) Q91VT4 (/ISS)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
3 Q7TS56 (/ISS) Q8N4T8 (/ISS) Q91VT4 (/ISS)
NAD(P)H dehydrogenase (quinone) activity GO:0003955
Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone.
1 Q8N4T8 (/IDA)
NAD(P)H dehydrogenase (quinone) activity GO:0003955
Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone.
1 Q91VT4 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q8N4T8 (/IPI)
NADPH dehydrogenase (quinone) activity GO:0008753
Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol.
1 Q8N4T8 (/IDA)
NADPH dehydrogenase (quinone) activity GO:0008753
Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol.
1 Q91VT4 (/ISO)
3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity GO:0047025
Catalysis of the reaction: NAD+ + OH-acyl-
1 Q8N4T8 (/IMP)
3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity GO:0047025
Catalysis of the reaction: NAD+ + OH-acyl-
1 Q91VT4 (/ISO)
Quinone binding GO:0048038
Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.
1 Q8N4T8 (/IDA)
Quinone binding GO:0048038
Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.
1 Q91VT4 (/ISO)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
1 Q8N4T8 (/IDA)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
1 Q91VT4 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
6 A4IFA7 (/ISS) Q68ER2 (/ISS) Q6NUE2 (/ISS) Q6P0H7 (/ISS) Q7TS56 (/ISS) Q91VT4 (/ISS)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
6 A4IFA7 (/ISS) Q68ER2 (/ISS) Q6NUE2 (/ISS) Q6P0H7 (/ISS) Q7TS56 (/ISS) Q91VT4 (/ISS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
6 A4IFA7 (/ISS) Q68ER2 (/ISS) Q6NUE2 (/ISS) Q6P0H7 (/ISS) Q7TS56 (/ISS) Q91VT4 (/ISS)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 Q8N4T8 (/IMP)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 Q91VT4 (/ISO)
Daunorubicin metabolic process GO:0044597
The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer.
1 Q8N4T8 (/IMP)
Daunorubicin metabolic process GO:0044597
The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer.
1 Q91VT4 (/ISO)
Doxorubicin metabolic process GO:0044598
The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy.
1 Q8N4T8 (/IMP)
Doxorubicin metabolic process GO:0044598
The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy.
1 Q91VT4 (/ISO)
Fatty-acyl-CoA biosynthetic process GO:0046949
The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.
1 Q8N4T8 (/TAS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q8N4T8 (/IPI)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q91VT4 (/ISO)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
1 Q8N4T8 (/IDA)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
1 Q91VT4 (/ISO)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q8N4T8 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q91VT4 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
7 A4IFA7 (/ISS) Q68ER2 (/ISS) Q6NUE2 (/ISS) Q6P0H7 (/ISS) Q7TS56 (/ISS) Q8N4T8 (/ISS) Q91VT4 (/ISS)
Oxidoreductase complex GO:1990204
Any protein complex that possesses oxidoreductase activity.
6 A4IFA7 (/ISS) Q68ER2 (/ISS) Q6NUE2 (/ISS) Q6P0H7 (/ISS) Q7TS56 (/ISS) Q91VT4 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q91VT4 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q8N4T8 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q91VT4 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q8N4T8 (/TAS)
Oxidoreductase complex GO:1990204
Any protein complex that possesses oxidoreductase activity.
1 Q8N4T8 (/IMP)
Oxidoreductase complex GO:1990204
Any protein complex that possesses oxidoreductase activity.
1 Q91VT4 (/ISO)