The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 284469: Ubiquitin-like modifier-activating enzyme 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
UFM1 activating enzyme activity GO:0071566
Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond.
8 A7MAZ3 (/ISS) Q3KQ23 (/ISS) Q5M7A4 (/ISS) Q5R8X4 (/ISS) Q6GLG7 (/ISS) Q6IVA4 (/ISS) Q8VE47 (/ISS) Q9VYY3 (/ISS)
Small protein activating enzyme activity GO:0008641
Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.
2 Q38EW4 (/ISO) Q4QF87 (/ISO)
Ubiquitin-like protein binding GO:0032182
Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein.
2 Q38EW4 (/ISO) Q4QF87 (/ISO)
UFM1 activating enzyme activity GO:0071566
Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond.
2 P91430 (/IDA) Q9GZZ9 (/IDA)
UFM1 activating enzyme activity GO:0071566
Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond.
2 Q8VE47 (/IMP) Q9GZZ9 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9GZZ9 (/IPI)
Ubiquitin conjugating enzyme binding GO:0031624
Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
1 P91430 (/IPI)
UFM1 activating enzyme activity GO:0071566
Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond.
1 Q8VE47 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein ufmylation GO:0071569
Covalent attachment of the ubiquitin-like protein UFM1 to another protein.
7 A7MAZ3 (/ISS) Q3KQ23 (/ISS) Q5M7A4 (/ISS) Q5R8X4 (/ISS) Q6GLG7 (/ISS) Q6IVA4 (/ISS) Q9VYY3 (/ISS)
Protein K69-linked ufmylation GO:1990592
A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein.
7 A7MAZ3 (/ISS) Q3KQ23 (/ISS) Q5M7A4 (/ISS) Q5R8X4 (/ISS) Q6GLG7 (/ISS) Q6IVA4 (/ISS) Q8VE47 (/ISS)
Regulation of intracellular estrogen receptor signaling pathway GO:0033146
Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
4 A7MAZ3 (/ISS) Q5M7A4 (/ISS) Q5R8X4 (/ISS) Q8VE47 (/ISS)
Protein ufmylation GO:0071569
Covalent attachment of the ubiquitin-like protein UFM1 to another protein.
2 Q8VE47 (/IDA) Q9GZZ9 (/IDA)
Reproduction GO:0000003
The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
1 P91430 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 X1WER2 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 P91430 (/IMP)
Locomotion involved in locomotory behavior GO:0031987
Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
1 Q9VYY3 (/IMP)
Regulation of intracellular estrogen receptor signaling pathway GO:0033146
Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
1 Q9GZZ9 (/IMP)
Regulation of intracellular estrogen receptor signaling pathway GO:0033146
Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
1 Q8VE47 (/ISO)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
1 Q9GZZ9 (/IDA)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
1 Q8VE47 (/ISO)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
1 X1WER2 (/IMP)
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 Q9VYY3 (/IMP)
Protein ufmylation GO:0071569
Covalent attachment of the ubiquitin-like protein UFM1 to another protein.
1 Q9GZZ9 (/IMP)
Protein ufmylation GO:0071569
Covalent attachment of the ubiquitin-like protein UFM1 to another protein.
1 Q8VE47 (/ISO)
Stress response to metal ion GO:0097501
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus.
1 P91430 (/IMP)
Protein K69-linked ufmylation GO:1990592
A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein.
1 Q9GZZ9 (/IDA)
Protein K69-linked ufmylation GO:1990592
A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein.
1 Q8VE47 (/ISO)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 A7MAZ3 (/ISS) Q5M7A4 (/ISS) Q5R8X4 (/ISS) Q8VE47 (/ISS) Q9VYY3 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 E7EQ61 (/IDA) E7EWE1 (/IDA) O23034 (/IDA) Q9GZZ9 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
3 E7EQ61 (/IDA) E7EWE1 (/IDA) Q9GZZ9 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q38EW4 (/ISO) Q4QF87 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9GZZ9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8VE47 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8VE47 (/ISO)
Molybdopterin synthase complex GO:0019008
A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits.
1 Q9VYY3 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q8VE47 (/ISO)