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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 177702: Oxidoreductase Rmd

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
GDP-4-dehydro-6-deoxy-D-mannose reductase. [EC: 1.1.1.281]
GDP-alpha-D-rhamnose + NAD(P)(+) = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H.
  • Differs from EC 1.1.1.187 in that the only product formed is GDP- alpha-D-rhamnose (GDP-6-deoxy-alpha-D-mannose).
  • D-rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.
 17 A0A071L2P8 A0A0C7CSV1 A0A0E1B2I7 A0A0H2ZIL5 A0A0H3QRF5 A0A0M4NUK5 A0A0P1DIK3 A0A157VLX3 A0A1C7BPE5 A0A1D5BU35
(7 more...)
GDP-mannose 4,6-dehydratase. [EC: 4.2.1.47]
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H(2)O.
  • Forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-alpha-L-fucose.
  • In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalyzing the above reaction as well as the reaction catalyzed by EC 1.1.1.281.
 8 A0A071L2P8 A0A0E1B2I7 A0A0H2ZIL5 A0A157VLX3 A0A1C7BPE5 A0A1G5LQD3 V6APQ4 W1MTW4