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CATH Superfamily 3.40.50.620

HUPs

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
HUPs
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 89168: Asparagine synthetase [glutamine-hydrolyzing] 1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Asparagine synthase (glutamine-hydrolyzing). [EC: 6.3.5.4]
ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate.
  • The enzyme from Escherichia coli has two active sites that are connected by an intramolecular ammonia tunnel.
  • The enzyme catalyzes three distinct chemical reactions: glutamine hydrolysis to yield ammonia takes place in the N-terminal domain.
  • The C-terminal active site mediates both the synthesis of a beta- aspartyl-AMP intermediate and its subsequent reaction with ammonia.
  • The ammonia released is channeled to the other active site to yield asparagine.
 3522 A0A015RX14 A0A015RX14 A0A015RYT9 A0A015RYT9 A0A015S3N2 A0A015S3N2 A0A015S4M5 A0A015S4M5 A0A015U7F7 A0A015U7F7
(3512 more...)
Glutamine--fructose-6-phosphate transaminase (isomerizing). [EC: 2.6.1.16]
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.
  • Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination).
  • Formerly EC 5.3.1.19.
 12 A0A150IKG4 A0A150IKG4 A0A150ITX9 A0A150ITX9 A0A150IY44 A0A150IY44 A0A150J9V3 A0A150J9V3 A0A150JFU0 A0A150JFU0
(2 more...)
Amidophosphoribosyltransferase. [EC: 2.4.2.14]
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O.
    		 8 A0A0T8PIA6 A0A0T8PIA6 A0A0U0NHY1 A0A0U0NHY1 A0A0X9I6J7 A0A0X9I6J7 A0A1C4C5Q1 A0A1C4C5Q1