The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

P-loop containing nucleotide triphosphate hydrolases

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 634883: ATP-dependent DNA helicase RuvB

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA helicase. [EC:]
ATP + H(2)O = ADP + phosphate.
  • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
  • Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15).
  • Some helicases unwind DNA as well as RNA (4,9).
  • May be identical with EC (RNA helicase).
13572 A0A009FBZ5 A0A009H3G3 A0A009H8K1 A0A009HEP3 A0A009HQY6 A0A009JZX5 A0A009KEL4 A0A009KUD8 A0A009NGL3 A0A009PRT8
(13562 more...)
Crossover junction endodeoxyribonuclease. [EC:]
Endonucleolytic cleavage at a junction such as a reciprocal single- stranded crossover between two homologous DNA duplexes (Holliday junction).
  • The enzyme from Saccharomyces cerevisiae has no endonuclease or exonuclease activity on single-stranded or double-stranded DNA molecules that do not contain Holliday junctions.
8 A0A1M4M792 A0A1M7V455 A0A1N7SA51 A0A1N7SV27 E6PDW3 E6Q2M3 K1XMX8 Q5L686
S-adenosylmethionine:tRNA ribosyltransferase-isomerase. [EC:]
S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.
  • The reaction is a combined transfer and isomerization of the ribose moiety of S-adenosyl-L-methionine to the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn.
  • It is part of the queuosine biosynthesis pathway.
1 A0A0G0NFD9