The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 151905: Sigma-54-dependent transcriptional response regula...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
9 Q48CE7 (/ISS) Q5LKZ2 (/ISS) Q5LQ67 (/ISS) Q5LS76 (/ISS) Q88AN6 (/ISS) Q9KLN9 (/ISS) Q9KN24 (/ISS) Q9KNI9 (/ISS) Q9KQS2 (/ISS)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
5 I7CA98 (/IPI) P10958 (/IPI) Q74EF9 (/IPI) Q88CY1 (/IPI) Q9KQ67 (/IPI)
Bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
5 I7CA98 (/IPI) P10958 (/IPI) Q74EF9 (/IPI) Q88CY1 (/IPI) Q9KQ67 (/IPI)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
4 I7CA98 (/EXP) Q74EF9 (/EXP) Q88CY1 (/EXP) Q9KQ67 (/EXP)
Bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
3 I7CA98 (/EXP) Q74EF9 (/EXP) Q9KQ67 (/EXP)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
2 I7CA98 (/IDA) Q74EF9 (/IDA)
Bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
2 I7CA98 (/IDA) Q74EF9 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q5LKZ2 (/ISS) Q5LS76 (/ISS)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
2 Q06065 (/ISS) Q2GHC4 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P0AFB8 (/IPI) Q72DI3 (/IPI)
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
1 P14375 (/IDA)
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
1 P0AFU4 (/IMP)
Bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 Q88CY1 (/EXP)
Bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 Q88CY1 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P14375 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 Q06065 (/IDA)
Ornithine decarboxylase inhibitor activity GO:0008073
The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase.
1 Q06065 (/IDA)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
9 Q48CE7 (/ISS) Q5LKZ2 (/ISS) Q5LQ67 (/ISS) Q5LS76 (/ISS) Q88AN6 (/ISS) Q9KLN9 (/ISS) Q9KN24 (/ISS) Q9KNI9 (/ISS) Q9KQS2 (/ISS)
C4-dicarboxylate transport GO:0015740
The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.
5 Q5LKZ2 (/ISS) Q5LQ67 (/ISS) Q5LS76 (/ISS) Q9KN24 (/ISS) Q9KQS2 (/ISS)
Regulation of nitrogen utilization GO:0006808
Any process that modulates the frequency, rate or extent of nitrogen utilization.
3 Q48CE7 (/ISS) Q88AN6 (/ISS) Q9KNI9 (/ISS)
Nitrogen fixation GO:0009399
The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide.
3 Q5LRN8 (/ISS) Q5LRP0 (/ISS) Q603F8 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 P0AFU4 (/ISS) P14375 (/ISS) Q06065 (/ISS)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
2 P0AFU4 (/ISS) P14375 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P10958 (/EXP) Q74D24 (/EXP)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
1 P14375 (/IDA)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
1 P0AFU4 (/IMP)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 P0AFU4 (/IDA)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 P14375 (/IEP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P0AFU4 (/IEP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P03029 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q2GHC4 (/ISS)
Bioluminescence GO:0008218
The production of light by certain enzyme-catalyzed reactions in cells.
1 Q5E6B4 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q1DDD5 (/IMP)
Regulation of polyamine biosynthetic process GO:0010967
Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups.
1 Q06065 (/IDA)
Nitrogen utilization GO:0019740
A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism.
1 Q74EZ8 (/ISS)
Positive regulation of organic acid transport GO:0032892
Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9HU19 (/IMP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
1 Q1D7F8 (/IMP)
Regulation of sporulation GO:0043937
Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure.
1 Q1D7F8 (/IMP)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 Q9I4N3 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q88CY1 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q06065 (/IDA)
Regulation of cell projection assembly GO:0060491
Any process that modulates the rate, frequency, or extent of cell projection assembly.
1 Q00934 (/IMP)
Negative regulation of single-species biofilm formation GO:1900191
Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation.
1 Q9I4N3 (/IMP)
Positive regulation of single-species biofilm formation on inanimate substrate GO:1900233
Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
1 Q9HT62 (/IMP)
Positive regulation of cilium-dependent cell motility GO:2000155
Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility.
1 Q9I4N3 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
5 I7CA98 (/IPI) P10958 (/IPI) Q74EF9 (/IPI) Q88CY1 (/IPI) Q9KQ67 (/IPI)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
4 I7CA98 (/EXP) Q74EF9 (/EXP) Q88CY1 (/EXP) Q9KQ67 (/EXP)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
2 I7CA98 (/IDA) Q74EF9 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P0AFB8 (/IDA)