The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 151905: Sigma-54-dependent transcriptional response regula...

There are 17 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Histidine kinase. [EC: 2.7.13.3]
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
  • This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine).
  • A number of histones can act as acceptor.
89 A0A0D2JD06 A0A0F2NCY3 A0A0F2QQX6 A0A0F2QW80 A0A0G8BMD2 A0A0K9I618 A0A0M2X1N7 A0A0S7YTD2 A0A0S7YTN9 A0A0S8CXM0
(79 more...)
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
85 A0A073KK07 A0A073KML9 A0A084ZQ71 A0A084ZT18 A0A085A8W8 A0A085FZ49 A0A085G3R5 A0A085G5R0 A0A085GM15 A0A085GNE1
(75 more...)
UDP-3-O-acyl-N-acetylglucosamine deacetylase. [EC: 3.5.1.108]
UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
  • The enzyme catalyzes a committed step in the biosynthesis of lipid A.
  • Formerly EC 3.5.1.n1.
63 A0A0A2HW86 A0A0F2NA94 A0A0G4K8S8 A0A0J6YSY5 A0A193FA85 A0A1E5NHX7 A0A1E5NLE4 A0A1E5NTP1 A0A1E7GRT7 A0A1E7HFN5
(53 more...)
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase. [EC: 6.3.2.9]
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.
  • Involved in the synthesis of a cell-wall peptide in bacteria.
36 A0A060UV32 A0A0A6H6U4 A0A0E1JIC5 A0A0E2M691 A0A0H3GGU1 A0A0J2GHR6 A0A0M1T2L2 A0A0T5XIC2 A0A0W2SKR1 A0A0W8ALV3
(26 more...)
Protein-glutamate methylesterase. [EC: 3.1.1.61]
Protein L-glutamate O(5)-methyl ester + H(2)O = protein L-glutamate + methanol.
  • Hydrolyzes the products of EC 2.1.1.77, EC 2.1.1.78, EC 2.1.1.80 and EC 2.1.1.100.
34 A0A095XRQ4 A0A0D8KW93 A0A0H3KBA4 A0A0N1AUF2 A0A0N1B8B6 A0A0Q7P502 A0A102DE36 A0A124JVT6 A0A126P2U1 A0A126RLA7
(24 more...)
Cyclic-guanylate-specific phosphodiesterase. [EC: 3.1.4.52]
Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine.
  • Inhibited by Ca(2+) and Zn(2+).
  • Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive.
  • It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.
26 A0A098MYB6 A0A0C5X254 A0A0C5X812 A0A0E2CXJ6 A0A0E2D498 A0A0F6H7Z4 A0A0F6HU31 A0A0F6IKD3 A0A0M3TLU4 A0A0M4NBM3
(16 more...)
(S)-limonene 7-monooxygenase. [EC: 1.14.13.49]
(-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.
  • High specificity, but NADH can act instead of NADPH, although more slowly.
18 A0A098MYB6 A0A0C5X254 A0A0E2CXJ6 A0A0E2D498 A0A0F6H7Z4 A0A0F6HU31 A0A0F6IKD3 A0A0M3TLU4 A0A109IBF8 A0A161QDU5
(8 more...)
Protein-glutamine glutaminase. [EC: 3.5.1.44]
Protein L-glutamine + H(2)O = protein L-glutamate + NH(3).
  • Specific for the hydrolysis of the gamma-amide of glutamine substituted at the carboxyl position or both the alpha-amino and carboxyl positions, e.g., L-glutaminylglycine and L-phenylalanyl-L- glutaminylglycine.
18 A0A098MYB6 A0A0C5X254 A0A0E2CXJ6 A0A0E2D498 A0A0F6H7Z4 A0A0F6HU31 A0A0F6IKD3 A0A0M3TLU4 A0A109IBF8 A0A161QDU5
(8 more...)
Perillyl-alcohol dehydrogenase. [EC: 1.1.1.144]
Perillyl alcohol + NAD(+) = perillyl aldehyde + NADH.
  • Oxidizes a number of primary alcohols with the alcohol group allylic to an endocyclic double bond and a 6-membered ring, either aromatic or hydroaromatic.
18 A0A098MYB6 A0A0C5X254 A0A0E2CXJ6 A0A0E2D498 A0A0F6H7Z4 A0A0F6HU31 A0A0F6IKD3 A0A0M3TLU4 A0A109IBF8 A0A161QDU5
(8 more...)
(S)-limonene 6-monooxygenase. [EC: 1.14.13.48]
(-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O.
  • High specificity, but NADH can act instead of NADPH, although more slowly.
18 A0A098MYB6 A0A0C5X254 A0A0E2CXJ6 A0A0E2D498 A0A0F6H7Z4 A0A0F6HU31 A0A0F6IKD3 A0A0M3TLU4 A0A109IBF8 A0A161QDU5
(8 more...)
Carveol dehydrogenase. [EC: 1.1.1.243]
(-)-trans-carveol + NADP(+) = (-)-carvone + NADPH.
    18 A0A098MYB6 A0A0C5X254 A0A0E2CXJ6 A0A0E2D498 A0A0F6H7Z4 A0A0F6HU31 A0A0F6IKD3 A0A0M3TLU4 A0A109IBF8 A0A161QDU5
    (8 more...)
    Endopeptidase La. [EC: 3.4.21.53]
    Hydrolysis of proteins in presence of ATP.
    • ATP hydrolysis is linked with peptide bond hydrolysis.
    • Vanadate inhibits both reactions.
    • A similar enzyme occurs in animal mitochondria.
    • Belongs to peptidase family S16.
    3 A0A0H3A6N7 C7LSZ5 F2NHG2
    Phosphoserine phosphatase. [EC: 3.1.3.3]
    O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate.
      2 A0A0B2D6I9 W0H780
      Protein-glutamate O-methyltransferase. [EC: 2.1.1.80]
      S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.
      • Forms ester groups with L-glutamate residues in a number of membrane proteins.
      • Formerly EC 2.1.1.24.
      1 A0A0F4FKR4
      Glucose-6-phosphate isomerase. [EC: 5.3.1.9]
      D-glucose 6-phosphate = D-fructose 6-phosphate.
      • Also catalyzes the anomerization of D-glucose 6-phosphate.
      1 A0A0L8ERB5
      CoB--CoM heterodisulfide reductase. [EC: 1.8.98.1]
      Coenzyme B + coenzyme M + methanophenazine = N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L-threonine + dihydromethanophenazine.
      • Found in methanogenic archaea, particularly Methanosarcina species, and regenerates coenzyme M and coenzyme B after the action of EC 2.8.4.1.
      • Highly specific for both coenzyme M and coenzyme B.
      • Reacts with various phenazine derivatives, including 2-hydroxyphenazine and 2-bromophenazine.
      • Formerly EC 1.12.99.2.
      1 C0QEM8
      Adenosine deaminase. [EC: 3.5.4.4]
      Adenosine + H(2)O = inosine + NH(3).
        1 A8T6C7