The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 151766: Transcriptional regulator, LacI family

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
12 A0A0C6FYN7 (/IDA) A8AWB2 (/IDA) F9UQH6 (/IDA) G5L2G2 (/IDA) N0CDN9 (/IDA) P0ACN7 (/IDA) P25144 (/IDA) Q03AX7 (/IDA) Q18AR8 (/IDA) Q8EBJ8 (/IDA)
(2 more)
Bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
11 A0A0C6FYN7 (/IDA) A8AWB2 (/IDA) F9UQH6 (/IDA) G5L2G2 (/IDA) N0CDN9 (/IDA) P25144 (/IDA) Q03AX7 (/IDA) Q18AR8 (/IDA) Q8EBJ8 (/IDA) Q9A3Y5 (/IDA)
(1 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
7 A0A0C6FYN7 (/EXP) A8AWB2 (/EXP) F9UQH6 (/EXP) G5L2G2 (/EXP) P25144 (/EXP) Q8EBJ8 (/EXP) Q9A3Y5 (/EXP)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
7 P24242 (/ISS) Q9KN33 (/ISS) Q9KNQ4 (/ISS) Q9KPM9 (/ISS) Q9KRC1 (/ISS) Q9KRS9 (/ISS) Q9KSH0 (/ISS)
Bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
6 A0A0C6FYN7 (/EXP) A8AWB2 (/EXP) F9UQH6 (/EXP) G5L2G2 (/EXP) Q8EBJ8 (/EXP) Q9A3Y5 (/EXP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P03024 (/IPI) P0ACN7 (/IPI) P0ACP7 (/IPI) P0ACQ0 (/IPI) P25144 (/IPI) P25748 (/IPI)
Bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
4 G5L2G2 (/IDA) P0ACQ0 (/IDA) P25144 (/IDA) Q18AR8 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
3 F9UQH6 (/IPI) P25144 (/IPI) Q03AX7 (/IPI)
Bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
3 A0A0C6FYN7 (/EXP) G5L2G2 (/EXP) P25144 (/EXP)
Bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
3 F9UQH6 (/IPI) P25144 (/IPI) Q03AX7 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 P03024 (/IDA) P0ACP7 (/IDA) P25748 (/IDA)
Bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding GO:0000986
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase.
2 P03023 (/IDA) P0ACQ0 (/IDA)
Bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding GO:0001130
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 A0A0C6FYN7 (/IDA)
Transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding GO:0001141
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to stop, prevent, or reduce the frequency, rate or extent of transcription from a bacterial-type RNA polymerase promoter.
1 P03023 (/IDA)
Bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 P25144 (/IPI)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 P24242 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P03024 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 P24242 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 P24242 (/ISS)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
12 A0A0C6FYN7 (/EXP) A8AWB2 (/EXP) F9UQH6 (/EXP) G5L2G2 (/EXP) N0CDN9 (/EXP) P25144 (/EXP) Q03AX7 (/EXP) Q18AR8 (/EXP) Q2G295 (/EXP) Q8EBJ8 (/EXP)
(2 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
8 Q81KR1 (/ISS) Q81V39 (/ISS) Q9KN33 (/ISS) Q9KNQ4 (/ISS) Q9KPM9 (/ISS) Q9KRC1 (/ISS) Q9KRS9 (/ISS) Q9KSH0 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 A0A0C6FYN7 (/EXP) G5L2G2 (/EXP) P25144 (/EXP) Q18AR8 (/EXP) Q9CF33 (/EXP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 F9UQH6 (/IEP) P25144 (/IEP) Q03AX7 (/IEP)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
2 Q81KR1 (/ISS) Q81V39 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 G5L2G2 (/EXP) Q18AR8 (/EXP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 P03024 (/IDA) P25748 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P03023 (/IMP) P0ACN7 (/IMP)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
1 P0ACP7 (/IDA)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 P03024 (/IDA)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 P24242 (/IEP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P24242 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P24242 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P25144 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P0ACQ0 (/IEP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
11 A0A0C6FYN7 (/IDA) A8AWB2 (/IDA) F9UQH6 (/IDA) G5L2G2 (/IDA) N0CDN9 (/IDA) P25144 (/IDA) Q03AX7 (/IDA) Q18AR8 (/IDA) Q8EBJ8 (/IDA) Q9A3Y5 (/IDA)
(1 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
7 A0A0C6FYN7 (/EXP) A8AWB2 (/EXP) F9UQH6 (/EXP) G5L2G2 (/EXP) P25144 (/EXP) Q8EBJ8 (/EXP) Q9A3Y5 (/EXP)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P03023 (/IDA) P0ACN7 (/IDA) P0ACP7 (/IDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
3 F9UQH6 (/IPI) P25144 (/IPI) Q03AX7 (/IPI)