The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 115645: Acyl-protein thioesterase 1 homolog 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Palmitoyl-(protein) hydrolase activity GO:0008474
Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
6 O77821 (/ISS) P70470 (/ISS) P97823 (/ISS) Q12354 (/ISS) Q3MHR0 (/ISS) Q5RBR7 (/ISS)
Carboxylic ester hydrolase activity GO:0052689
Catalysis of the hydrolysis of a carboxylic ester bond.
6 C0PDF4 (/IDA) M9PEW1 (/IDA) P76561 (/IDA) Q8GYK2 (/IDA) Q9HXE7 (/IDA) Q9I7R0 (/IDA)
Palmitoyl-(protein) hydrolase activity GO:0008474
Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
2 O75608 (/IMP) Q12354 (/IMP)
Palmitoyl-(protein) hydrolase activity GO:0008474
Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
2 O42881 (/ISO) P97823 (/ISO)
Palmitoyl-(protein) hydrolase activity GO:0008474
Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
2 O75608 (/TAS) O95372 (/TAS)
Lysophospholipase activity GO:0004622
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
1 P70470 (/IDA)
Lysophospholipase activity GO:0004622
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
1 Q5VWZ2 (/NAS)
Lysophospholipase activity GO:0004622
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
1 O75608 (/TAS)
Phospholipase A2 activity GO:0004623
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
1 Q84WK4 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q6IAQ1 (/IPI)
Palmitoyl-(protein) hydrolase activity GO:0008474
Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
1 Q12354 (/IDA)
Lipase activity GO:0016298
Catalysis of the hydrolysis of a lipid or phospholipid.
1 O75608 (/IDA)
Lipase activity GO:0016298
Catalysis of the hydrolysis of a lipid or phospholipid.
1 P97823 (/ISO)
Hydrolase activity, acting on ester bonds GO:0016788
Catalysis of the hydrolysis of any ester bond.
1 P76561 (/IDA)
Short-chain carboxylesterase activity GO:0034338
Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.
1 Q84WK4 (/IDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 O95372 (/IDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 Q9WTL7 (/ISO)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein depalmitoylation GO:0002084
The removal of palymitoyl groups from a lipoprotein.
2 P97823 (/IMP) Q3UFF7 (/IMP)
Negative regulation of Golgi to plasma membrane protein transport GO:0042997
Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
2 P97823 (/IMP) Q3UFF7 (/IMP)
Protein depalmitoylation GO:0002084
The removal of palymitoyl groups from a lipoprotein.
1 O42881 (/ISO)
Phosphatidic acid biosynthetic process GO:0006654
The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
1 Q84WK4 (/IDA)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 O95372 (/TAS)
Defense response, incompatible interaction GO:0009814
A response of a plant to a pathogenic agent that prevents the occurrence or spread of disease.
1 Q8GYK2 (/IMP)
Defense response to bacterium, incompatible interaction GO:0009816
A response of an organism to a bacterium that prevents the occurrence or spread of disease.
1 Q84WK4 (/IMP)
Regulation of plant-type hypersensitive response GO:0010363
Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response.
1 Q8GYK2 (/IMP)
Protein deacylation GO:0035601
The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid.
1 Q12354 (/IDA)
Protein deacylation GO:0035601
The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid.
1 Q12354 (/IMP)
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
1 O75608 (/TAS)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 C0PDF4 (/IDA) M9PEW1 (/IDA) O95372 (/IDA) Q9I7R0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 O42881 (/IDA) P97823 (/IDA) Q3UFF7 (/IDA) Q5VWZ2 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 O75608 (/IDA) O95372 (/IDA) Q5VWZ2 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P97823 (/ISO) Q3UFF7 (/ISO) Q9WTL7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O75608 (/TAS) O95372 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O42881 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9WTL7 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P97823 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q3UFF7 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8GYK2 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q55FK4 (/IDA)
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