The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6118: Purine nucleoside phosphorylase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Purine-nucleoside phosphorylase activity GO:0004731
Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
7 P00491 (/IDA) P23492 (/IDA) P45563 (/IDA) P55859 (/IDA) P85973 (/IDA) P9WP01 (/IDA) Q05788 (/IDA)
S-methyl-5-thioadenosine phosphorylase activity GO:0017061
Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.
3 A0A0G2K583 (/IDA) Q07938 (/IDA) Q7TP15 (/IDA)
S-methyl-5-thioadenosine phosphorylase activity GO:0017061
Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.
3 A0A0G2K583 (/IMP) Q07938 (/IMP) Q7TP15 (/IMP)
Nucleoside binding GO:0001882
Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.
2 P23492 (/ISO) Q9D8C9 (/ISO)
Purine nucleobase binding GO:0002060
Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton.
2 P23492 (/ISO) Q9D8C9 (/ISO)
Purine-nucleoside phosphorylase activity GO:0004731
Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
2 P23492 (/IMP) Q05788 (/IMP)
Purine-nucleoside phosphorylase activity GO:0004731
Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
2 P23492 (/ISO) Q9UTG1 (/ISO)
Purine-nucleoside phosphorylase activity GO:0004731
Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
2 Q05788 (/ISS) Q83FC4 (/ISS)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
2 P23492 (/ISO) Q9D8C9 (/ISO)
Phosphate ion binding GO:0042301
Interacting selectively and non-covalently with phosphate.
2 P23492 (/ISO) Q9D8C9 (/ISO)
Inosine nucleosidase activity GO:0047724
Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine.
2 P45563 (/IDA) Q05788 (/IDA)
Nucleoside binding GO:0001882
Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.
1 P00491 (/IDA)
Purine nucleobase binding GO:0002060
Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton.
1 P00491 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q07938 (/IDA)
Phosphorylase activity GO:0004645
Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase.
1 Q13126 (/TAS)
Purine-nucleoside phosphorylase activity GO:0004731
Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
1 P00491 (/EXP)
Purine-nucleoside phosphorylase activity GO:0004731
Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
1 C8V0B3 (/RCA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q13126 (/IPI)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 P00491 (/IDA)
Thymidine phosphorylase activity GO:0009032
Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate.
1 C8V0B3 (/RCA)
S-methyl-5-thioadenosine phosphorylase activity GO:0017061
Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.
1 Q09816 (/ISO)
S-methyl-5-thioadenosine phosphorylase activity GO:0017061
Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.
1 Q74E52 (/ISS)
S-methyl-5-thioadenosine phosphorylase activity GO:0017061
Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.
1 Q13126 (/TAS)
Phosphate ion binding GO:0042301
Interacting selectively and non-covalently with phosphate.
1 P00491 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P45563 (/IDA)
Guanosine phosphorylase activity GO:0047975
Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate.
1 P45563 (/IDA)
Nicotinamide riboside hydrolase activity GO:0070635
Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose.
1 Q05788 (/IDA)

There are 63 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-methionine salvage from methylthioadenosine GO:0019509
The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.
3 A0A0G2K583 (/IMP) Q07938 (/IMP) Q7TP15 (/IMP)
Inosine catabolic process GO:0006148
The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.
2 P00491 (/IDA) P45563 (/IDA)
Inosine catabolic process GO:0006148
The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.
2 P23492 (/IMP) Q05788 (/IMP)
Deoxyguanosine catabolic process GO:0006161
The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose.
2 P45563 (/IDA) P9WP01 (/IDA)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
2 A0A0G2K583 (/IEP) Q7TP15 (/IEP)
NAD biosynthesis via nicotinamide riboside salvage pathway GO:0034356
The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside.
2 P00491 (/IGI) Q05788 (/IGI)
Purine nucleoside metabolic process GO:0042278
The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
2 P23492 (/IDA) P85973 (/IDA)
Purine-containing compound salvage GO:0043101
Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis.
2 P00491 (/TAS) P85973 (/TAS)
Guanosine catabolic process GO:0046115
The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution.
2 P23492 (/IMP) Q05788 (/IMP)
Positive regulation of T cell mediated cytotoxicity GO:0001916
Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
1 P23492 (/IMP)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
1 P00491 (/IDA)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
1 C8V0B3 (/RCA)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
1 Q13126 (/TAS)
Inosine catabolic process GO:0006148
The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.
1 P23492 (/ISO)
Deoxyinosine catabolic process GO:0006149
The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside.
1 P45563 (/IDA)
Deoxyinosine catabolic process GO:0006149
The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside.
1 P23492 (/IMP)
Purine nucleoside catabolic process GO:0006152
The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
1 P45563 (/IDA)
Purine nucleoside catabolic process GO:0006152
The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
1 P45563 (/IMP)
Purine nucleoside catabolic process GO:0006152
The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
1 Q9UTG1 (/ISO)
Deoxyguanosine catabolic process GO:0006161
The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose.
1 P23492 (/IMP)
Purine ribonucleoside salvage GO:0006166
Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis.
1 Q83FC4 (/ISS)
Adenine salvage GO:0006168
Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis.
1 Q74E52 (/ISS)
GTP biosynthetic process GO:0006183
The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate.
1 P23492 (/IMP)
Purine nucleotide catabolic process GO:0006195
The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
1 P00491 (/TAS)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
1 Q07938 (/IMP)
Nicotinamide riboside catabolic process GO:0006738
The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide.
1 P00491 (/IDA)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 P00491 (/IMP)
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
1 P23492 (/IMP)
Apoptotic mitochondrial changes GO:0008637
The morphological and physiological alterations undergone by mitochondria during apoptosis.
1 P23492 (/IMP)
Response to gamma radiation GO:0010332
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
1 P23492 (/IMP)
Nucleobase-containing small molecule interconversion GO:0015949
The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.
1 P45563 (/IMP)
Nicotinate nucleotide salvage GO:0019358
The generation of nicotinate nucleotide without de novo synthesis.
1 Q05788 (/IGI)
L-methionine salvage from methylthioadenosine GO:0019509
The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.
1 Q07938 (/IDA)
L-methionine salvage from methylthioadenosine GO:0019509
The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.
1 Q09816 (/ISO)
L-methionine salvage from methylthioadenosine GO:0019509
The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.
1 Q74E52 (/ISS)
L-methionine salvage from methylthioadenosine GO:0019509
The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.
1 Q13126 (/TAS)
Methylation GO:0032259
The process in which a methyl group is covalently attached to a molecule.
1 Q9CQ65 (/IMP)
Protein hexamerization GO:0034214
The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
1 P45563 (/IDA)
NAD biosynthesis via nicotinamide riboside salvage pathway GO:0034356
The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside.
1 Q9UTG1 (/ISO)
Urate biosynthetic process GO:0034418
The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine.
1 P00491 (/IDA)
Urate biosynthetic process GO:0034418
The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine.
1 P23492 (/IMP)
Urate biosynthetic process GO:0034418
The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine.
1 P23492 (/ISO)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 P00491 (/IDA)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 P23492 (/IMP)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 P23492 (/ISO)
Purine nucleoside metabolic process GO:0042278
The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
1 P23492 (/IC)
Purine nucleoside metabolic process GO:0042278
The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
1 P23492 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P00491 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P00491 (/IMP)
Nucleotide salvage GO:0043173
Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis.
1 C8V0B3 (/RCA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P00491 (/TAS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 U4PSA1 (/IEP)
Positive regulation of B cell differentiation GO:0045579
Any process that activates or increases the frequency, rate or extent of B cell differentiation.
1 P23492 (/IMP)
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
1 P23492 (/IMP)
DGTP metabolic process GO:0046070
The chemical reactions and pathways involving dGTP, guanosine triphosphate.
1 P23492 (/IMP)
Guanosine catabolic process GO:0046115
The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution.
1 P45563 (/IDA)
Positive regulation of alpha-beta T cell differentiation GO:0046638
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.
1 P00491 (/IDA)
Positive regulation of alpha-beta T cell differentiation GO:0046638
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.
1 P23492 (/IMP)
Positive regulation of alpha-beta T cell differentiation GO:0046638
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.
1 P23492 (/ISO)
Nucleobase-containing small molecule metabolic process GO:0055086
The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
1 P45563 (/IMP)
Negative regulation of T cell apoptotic process GO:0070233
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.
1 P23492 (/IMP)
Interleukin-2 secretion GO:0070970
The regulated release of interleukin-2 from a cell.
1 P00491 (/IMP)
Xanthosine catabolic process GO:1903228
The chemical reactions and pathways resulting in the breakdown of xanthosine.
1 P45563 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 B4DUC8 (/IDA) P23492 (/IDA) Q09816 (/IDA) Q13126 (/IDA) Q9UTG1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P00491 (/IDA) P45563 (/IDA) P85973 (/IDA) Q07938 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P85973 (/IDA) Q09816 (/IDA) Q9UTG1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P23492 (/ISO) Q09816 (/ISO) Q9D8C9 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P23492 (/ISO) Q9CQ65 (/ISO) Q9D8C9 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 C8VP37 (/IDA) P85973 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
2 P23492 (/ISO) Q9D8C9 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P00491 (/TAS) Q13126 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P00491 (/IDA) Q13126 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P00491 (/TAS)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 Q05788 (/IC)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 P00491 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9CQ65 (/ISO)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
1 P00491 (/TAS)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
1 P00491 (/TAS)