The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6118: Purine nucleoside phosphorylase 1

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Purine-nucleoside phosphorylase. [EC:]
(1) Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. (2) Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.
  • Specificity not completely determined.
  • Can also catalyze ribosyltransferase reactions of the type catalyzed by EC
15634 A0A010ZS62 A0A010ZS62 A0A011B2Q2 A0A011B2Q2 A0A011NJ19 A0A011NJ19 A0A011NW23 A0A011NW23 A0A011PML8 A0A011PML8
(15624 more...)
S-methyl-5'-thioadenosine phosphorylase. [EC:]
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha- D-ribose 1-phosphate.
  • Also acts on 5'-deoxyadenosine and other analogs having 5'-deoxy groups.
5536 A0A010RJM5 A0A010RJM5 A0A016WN71 A0A016WN71 A0A016WPB3 A0A016WPB3 A0A016X0C5 A0A016X0C5 A0A016X2N9 A0A016X2N9
(5526 more...)
S-methyl-5'-thioinosine phosphorylase. [EC:]
S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio- alpha-D-ribose 1-phosphate.
  • No activity with S-methyl-5'-thioadenosine.
  • The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC and phosphorolysis to hypoxanthine.
1566 A0A010SUD2 A0A010SUD2 A0A023NTA4 A0A023NTA4 A0A023WTE4 A0A023WTE4 A0A023Y0J4 A0A023Y0J4 A0A024EJ10 A0A024EJ10
(1556 more...)
DNA-directed RNA polymerase. [EC:]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
  • Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
  • Can initiate a chain de novo.
  • In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized.
  • See also EC and EC
(4 more...)
Adenine phosphoribosyltransferase. [EC:]
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
  • 5-amino-4-imidazolecarboxamide can replace adenine.
10 A0A0G0J1G8 A0A0G0J1G8 A0A1F4W0B1 A0A1F4W0B1 A0A1F6Z186 A0A1F6Z186 A0A1F6ZIQ0 A0A1F6ZIQ0 A0A1J5AGN5 A0A1J5AGN5
UDP-N-acetylmuramate--L-alanine ligase. [EC:]
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP- N-acetyl-alpha-D-muramoyl-L-alanine.
  • Involved in the synthesis of a cell-wall peptide.
Glycogen phosphorylase. [EC:]
((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.
  • This entry covers several enzymes from different sources that act in vivo on different forms of (1->4)-alpha-D-glucans.
  • Some of these enzymes catalyze the first step in the degradation of large branched glycan polymers - the phosphorolytic cleavage of alpha-1,4-glucosidic bonds from the non-reducing ends of linear poly(1->4)-alpha-D-glucosyl chains within the polymers.
  • The enzyme stops when it reaches the fourth residue away from an alpha-1,6 branching point, leaving a highly branched core known as a limit dextrin.
  • The description (accepted name) of the enzyme should be modified for each specific instance by substituting 'glycogen' with the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, etc.