The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

Vaccinia Virus protein VP39

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 135860: Ribosomal RNA large subunit methyltransferase K/L

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
23S rRNA (guanine(2445)-N(2))-methyltransferase. [EC:]
S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L- homocysteine + N(2)-methylguanine(2445) in 23S rRNA.
  • The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate.
  • The enzyme specifically methylates guanine(2445) at N(2) in 23S rRNA.
  • Formerly EC
6052 A0A010QC01 A0A010QC01 A0A010RV44 A0A010RV44 A0A011MV87 A0A011MV87 A0A011NA11 A0A011NA11 A0A011NJ06 A0A011NJ06
(6042 more...)
23S rRNA (guanine(2069)-N(7))-methyltransferase. [EC:]
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L- homocysteine + N(7)-methylguanine(2069) in 23S rRNA.
  • The enzyme specifically methylates guanine(2069) at position N7 in 23S rRNA.
  • In gamma-proteobacteria the enzyme also catalyzes EC, while in beta-proteobacteria the activities are carried out by separate proteins.
  • The enzyme from the gamma-proteobacterium Escherichia coli has RNA unwinding activity as well.
4822 A0A010QC01 A0A010QC01 A0A010RV44 A0A010RV44 A0A011NA11 A0A011NA11 A0A014NIS1 A0A014NIS1 A0A017IFY5 A0A017IFY5
(4812 more...)
16S rRNA (guanine(966)-N(2))-methyltransferase. [EC:]
S-adenosyl-L-methionine + guanine(966) in 16S rRNA = S-adenosyl-L- homocysteine + N(2)-methylguanine(966) in 16S rRNA.
  • The enzyme efficiently methylates guanine(966) of the assembled 30S subunits in vitro.
  • Protein-free 16S rRNA is not a substrate for RsmD.
  • The enzyme specifically methylates guanine(966) at N(2) in 16S rRNA.
  • Formerly EC
88 A0A0E0TBY7 A0A0E0TBY7 A0A0R1JEW0 A0A0R1JEW0 B0KCT3 B0KCT3 D9R5B3 D9R5B3 D9SE78 D9SE78
(78 more...)
Site-specific DNA-methyltransferase (adenine-specific). [EC:]
S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA.
  • This is a large group of enzymes, most of which form so-called 'restriction-modification systems', with nucleases that possess similar site specificity (the nucleases are listed as either EC, EC and EC
  • See the REBASE database for a complete list of these enzymes:
28 A0A0M1XBN7 A0A0M1XBN7 A0A0M1ZSK5 A0A0M1ZSK5 A0A0M2A225 A0A0M2A225 A0A0M2AKV5 A0A0M2AKV5 A0A132ZF82 A0A132ZF82
(18 more...)
TRNA (guanine(6)-N(2))-methyltransferase. [EC:]
S-adenosyl-L-methionine + guanine(6) in tRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(6) in tRNA.
  • The enzyme specifically methylates guanine(6) at N(2) in tRNA.
6 A0A075WGP5 A0A075WGP5 O28105 O28105 Q57880 Q57880
DNA (cytosine-5-)-methyltransferase. [EC:]
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
  • See the REBASE database for a complete list of these enzymes:
  • Formerly EC
4 A0A1A7T9Y0 A0A1A7T9Y0 R2R9K6 R2R9K6
Transferred entry:,, and [EC:]
    2 E0I4V2 E0I4V2