The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 135410: 23S rRNA N-6-methyltransferase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
23S rRNA (adenine(2085)-N(6))-dimethyltransferase. [EC: 2.1.1.184]
2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L- homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA.
  • ErmC is a methyltransferase that confers resistance to the macrolide- lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at adenine(2085).
  • Formerly EC 2.1.1.48.
12 A0A087APD7 A0A087CBZ1 A0A0B6EZC3 A0A0F5D7P2 A0A0K2WZ52 A0A1B9BF16 C2GL02 P07287 P09891 P45439
(2 more...)
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase. [EC: 2.1.1.182]
4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)- dimethyladenine(1519) in 16S rRNA.
  • KsgA introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine(1518) and adenine(1519) in 16S rRNA.
  • Strains lacking the methylase are resistant to kasugamycin.
  • Formerly EC 2.1.1.48.
12 A0A0E9GD84 A0A0K9EU45 A0A133Z410 A0A1F0QRV0 A0A1F1WSS2 A0A1N1EK41 B1VIT5 D6CJF0 Q0ZBC3 Q8RMK2
(2 more...)
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