The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Toll/interleukin-1 receptor homology (TIR) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
4403
2079
3D
1fywA00 - 83.9
4407
1465
3D
1t3gA00 - 94.2
4356
498 - - 89.6
4369
384
EC
- - 96.3
4353
261 - - 83.4
4333
237
3D
2js7A01 - 71.9
4390
234
3D
4c6rA00 - 81.8
4366
143 - - 86.6
4305
132
3D
2y92A00 - 62.4
4301
131 - - 59.6
4393
95
3D
2m1xA00 - 89.2
4312
86 - - 48.0
4336
79 - - 67.4
527
58 - - 38.9
526
54 - - 21.3
730
50 - - 18.9
1201
39 - - 46.2
4376
37
3D
3jrnA00 - 78.9
659
17 - - 22.6
1684
14 - - 4.8
1391
14 - - 11.7
1553
13 - - 8.5
2131
12 - - 16.1
2979
TIR-NBS class
9 - - 19.8
757
8 - - 25.1
1627
7 - - 28.7
1227
7 - - 1.4
3142
5 - - 3.4
2225
5 - - 4.6
4088
5
3D
4c6sA00 - 5.4
693
5 - - 13.1
574
4 - - 7.1
1681
3 - - 0.7
2961
3 - - 0.0
1101
2 - - 6.7
2031
2 - - 0.7
2456
2 - - 0.0
445
2 - - 4.8
105
TIR
1 - - 0.0
1820
1 - - 0.0
3103
1 - - 0.0
4089
1 - - 0.0
2278
1 - - 0.0
2251
1 - - 0.0
2065
1 - - 0.0