The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Collagenase (Catalytic Domain)
".
FunFam 13318: Disintegrin and metalloproteinase domain-containin...
There are 3 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
ADAM10 endopeptidase.
[EC: 3.4.24.81]
Endopeptidase of broad specificity.
|
18 |
A0A024R5U5
A0A061I1D6
A0A0B8RTY1
A0A1L2JAW4
B3VKE8
B7PJH9
B7QKW5
E0VKA6
E0VKC3
G1RKW3 (8 more...) |
ADAM 17 endopeptidase.
[EC: 3.4.24.86]
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
|
8 | B2RNB2 B7P464 E0VA01 H2R900 O77636 P78536 Q9Z0F8 Q9Z1K9 |
Acetate--CoA ligase.
[EC: 6.2.1.1]
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
|
1 | A0A0L1HUV5 |