The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

Collagenase (Catalytic Domain)

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13318: Disintegrin and metalloproteinase domain-containin...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
ADAM10 endopeptidase. [EC:]
Endopeptidase of broad specificity.
  • Partially responsible for the 'alpha-secretase' activity in brain that degrades the potentially harmful beta-amyloid peptide.
  • Work with ADAM10-deficient mice supports a role in Notch signaling.
  • Belongs to peptidase family M12.
18 A0A024R5U5 A0A061I1D6 A0A0B8RTY1 A0A1L2JAW4 B3VKE8 B7PJH9 B7QKW5 E0VKA6 E0VKC3 G1RKW3
(8 more...)
ADAM 17 endopeptidase. [EC:]
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
  • In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNF-alpha, which induces inflammation.
  • Belongs to peptidase family M12.
8 B2RNB2 B7P464 E0VA01 H2R900 O77636 P78536 Q9Z0F8 Q9Z1K9
Acetate--CoA ligase. [EC:]
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
  • Also acts on propanoate and propenoate.
1 A0A0L1HUV5