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CATH Superfamily 3.40.390.10

Collagenase (Catalytic Domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Collagenase (Catalytic Domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13228: Endothelin-converting enzyme (AFU_orthologue AFUA_...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Endothelin-converting enzyme 1. [EC: 3.4.24.71]
Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.
  • Phosphoramidon-sensitive.
  • Belongs to peptidase family M13.
 254 A0A024B5K5 A0A024RAF7 A0A061YX09 A0A077XPA9 A0A078PKZ4 A0A080N296 A0A081R8B7 A0A087EKQ5 A0A095AMY4 A0A095B650
(244 more...)
Neprilysin. [EC: 3.4.24.11]
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
  • A membrane-bound glycoprotein widely distributed in animal tissues.
  • Inhibited by phosphoramidon and thiorphan.
  • Belongs to peptidase family M13.
 78 A0A061IKC5 A0A061IQP5 A0A076JII9 A0A086Z1D5 A0A086ZIC6 A0A086ZK71 A0A086ZVX8 A0A087ABF1 A0A087AGL7 A0A087AI97
(68 more...)
Heparan-alpha-glucosaminide N-acetyltransferase. [EC: 2.3.1.78]
Acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide.
  • Brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed.
  • Also acts on heparin.
  • Not identical with EC 2.3.1.3 or EC 2.3.1.4.
 2 A0A0F4HD15 A0A0N7CKK0