View in Gene3D

CATH Superfamily 3.30.830.10

Metalloenzyme, LuxS/M16 peptidase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Metalloenzyme, LuxS/M16 peptidase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 16618: A-pheromone processing metallopeptidase Ste23

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pitrilysin. [EC: 3.4.24.55]
Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon.
  • From the periplasmic space of Escherichia coli.
  • Inhibited by EDTA and 1,10-phenanthroline; not thiol dependent.
  • Belongs to peptidase family M16.
  • Formerly EC 3.4.99.44.
 517 A0A017IAX6 A0A022PHQ4 A0A023Z1Q2 A0A024KP92 A0A024LA55 A0A025CWW2 A0A027U8D8 A0A028ECC0 A0A029HLL5 A0A029IKW5
(507 more...)
Insulysin. [EC: 3.4.24.56]
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
  • Cytosolic enzyme, known from mammals and Drosophila melanogaster.
  • Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon.
  • Belongs to peptidase family M16.
  • Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.
 20 A0A081NCD9 A0A099KAW6 A0A099KBG7 A0A099LAL7 A0A099LD07 A0A0B2PIF1 A0A0B2QXP2 A0A0F4YR92 A0A142BCG9 B8CPY1
(10 more...)