View in Gene3D

CATH Superfamily 3.30.70.420

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 385: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hydroxymethylglutaryl-CoA reductase. [EC: 1.1.1.88]
(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.
    		 48 A0A075WG19 A0A081Y3Z2 A0A085VA21 A0A0B1YXC0 A0A0B4XJ03 A0A0C5RSN5 A0A0D9B0Z7 A0A0F0F3K1 A0A0F3GAV4 A0A0J6G6B8
    (38 more...)
    Hydroxymethylglutaryl-CoA reductase (NADPH). [EC: 1.1.1.34]
    (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
    • The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.
    		 2 A0A075WG19 O28538