The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ORF SCO4226, nickel-binding ferredoxin-like monomer

This superfamily entry represents the open reading frame SCO4226 of Streptomyces coelicolor A3(2), which encodes an 82-residue hypothetical protein. According to Pfam, most of these proteins are found in bacteria and archaea, though are functionally uncharacterised. Biochemical assays revealed that each SCO4226 dimer binds four nickel ions. Each subunit of SCO4226 dimer adopts a canonical ferredoxin-like fold with five beta-strands flanked by two alpha-helices. In the structure of Ni-SCO4226, four nickel ions are coordinated at the surface of the dimer. Further biochemical assays suggested that the binding of Ni2+ triggers the self-aggregation of SCO4226 in vitro. All these results suggested that SCO4226 acts as a nickel binding protein, probably required for nickel sequestration and/or detoxification. Additionally, there is a single completely conserved residue C that may be functionally important.

DOI:10.1371/journal.pone.0109660, PFAM:PF14026, DUF4242, INTERPRO:IPR025336

GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
798 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 4
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 2
Unique GO:
Unique Species: 798