The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15869: NAD-dependent malic enzyme 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Malate dehydrogenase (oxaloacetate-decarboxylating). [EC: 1.1.1.38]
(1) (S)-malate + NAD(+) = pyruvate + CO(2) + NADH. (2) Oxaloacetate = pyruvate + CO(2).
  • Unlike EC 1.1.1.39, this enzyme can also decarboxylate oxaloacetate, cf. EC 1.1.1.40.
12 A0A063XD80 A0A0M0L4J5 A0A0T8PSN1 A0A125UJR7 A0A1B2B5M9 A0A1L3SI99 D4FYD1 G4EU77 G4NW52 L8ALD4
(2 more...)
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). [EC: 1.1.1.40]
(1) (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH. (2) Oxaloacetate = pyruvate + CO(2).
  • The enzyme catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate, cf. EC 1.1.1.38 and EC 1.1.1.39.
8 A0A063XD80 A0A0T8PSN1 A0A125UJR7 A0A1B2B5M9 D4FYD1 L8ALD4 P54572 U1ZAH9