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CATH Superfamily 3.30.559.10

Chloramphenicol acetyltransferase-like domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Chloramphenicol acetyltransferase-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22401: BAHD family acyltransferase, clade V

There are 23 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Shikimate O-hydroxycinnamoyltransferase. [EC: 2.3.1.133]
4-coumaroyl-CoA + shikimate = CoA + 4-coumaroylshikimate.
  • Caffeoyl-CoA, feruloyl-CoA and sinapoyl-CoA can also act as donors, more slowly.
 168 A0A0B2NRA3 A0A0B2NRA3 A0A0B2NVY8 A0A0B2NVY8 A0A0B2NWF7 A0A0B2NWF7 A0A0B2NYH3 A0A0B2NYH3 A0A0B2NZH8 A0A0B2NZH8
(158 more...)
Anthranilate N-benzoyltransferase. [EC: 2.3.1.144]
Benzoyl-CoA + anthranilate = CoA + N-benzoylanthranilate.
  • Cinnamoyl-CoA, 4-coumaroyl-CoA and salicyloyl-CoA can act as donors, more slowly.
  • Involved in the biosynthesis of phytoalexins.
 56 A0A0B2NRA3 A0A0B2NRA3 A0A0B2NWF7 A0A0B2NWF7 A0A0B2PW86 A0A0B2PW86 A0A0B2Q6H6 A0A0B2Q6H6 A0A0B2QA35 A0A0B2QA35
(46 more...)
Salutaridinol 7-O-acetyltransferase. [EC: 2.3.1.150]
Acetyl-CoA + salutaridinol = CoA + 7-O-acetylsalutaridinol.
  • At higher pH values the product, 7-O-acetylsalutaridinol, spontaneously closes the 4->5 oxide bridge by allylic elimination to form the morphine precursor thebaine.
  • From the opium poppy plant, Papaver somniferum.
 44 B9R8I4 B9R8I4 B9R8M3 B9R8M3 B9RAL2 B9RAL2 B9RAL6 B9RAL6 B9RAL7 B9RAL7
(34 more...)
Taxadien-5-alpha-ol O-acetyltransferase. [EC: 2.3.1.162]
Acetyl-CoA + taxa-4(20),11-dien-5-alpha-ol = CoA + taxa-4(20),11-dien-5- alpha-yl acetate.
  • This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas.
 18 B9R7Y9 B9R7Y9 B9RPA0 B9RPA0 B9RUQ5 B9RUQ5 B9RVG9 B9RVG9 B9SDE9 B9SDE9
(8 more...)
10-deacetylbaccatin III 10-O-acetyltransferase. [EC: 2.3.1.167]
Acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III.
  • The enzyme will not acylate the hydroxy group at 1-beta, 7-beta, 13-alpha of 10-deacetylbaccatin III, or at 5-alpha of taxa-4(20), 11-dien-5-alpha-ol.
  • May be identical to EC 2.3.1.163.
 12 B9RN49 B9RN49 B9S966 B9S966 B9SDF1 B9SDF1 B9SDF2 B9SDF2 Q6SQJ5 Q6SQJ5
(2 more...)
Quinate O-hydroxycinnamoyltransferase. [EC: 2.3.1.99]
Feruloyl-CoA + quinate = CoA + O-feruloylquinate.
  • Caffeoyl-CoA and 4-coumaroyl-CoA can also act as donors, more slowly.
  • Involved in the biosynthesis of chlorogenic acid in sweet potato and, with EC 2.3.1.98 in the formation of caffeoyl-CoA in tomato.
 12 A0A126Q9A5 A0A126Q9A5 A0A193BL31 A0A193BL31 A0A193BL33 A0A193BL33 A0A193BL34 A0A193BL34 H9N9G5 H9N9G5
(2 more...)
Rosmarinate synthase. [EC: 2.3.1.140]
Caffeoyl-CoA + (R)-3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate.
  • Involved with EC 1.1.1.237 in the biosynthesis of rosmarinic acid.
  • Characterized from the plant Melissa officinalis L. (lemon balm).
 8 A0A0A7RA06 A0A0A7RA06 A0PDV5 A0PDV5 F2YNI5 F2YNI5 G0LD36 G0LD36
Benzyl alcohol O-benzoyltransferase. [EC: 2.3.1.196]
Benzoyl-CoA + benzyl alcohol = CoA + benzyl benzoate.
  • The enzyme is involved in volatile benzenoid and benzoic acid biosynthesis.
  • The enzyme from Petunia hybrida also catalyzes the formation of 2-phenylethyl benzoate from benzoyl-CoA and 2-phenylethanol.
  • The apparent catalytic efficiency of the enzyme from Petunia hybrida with benzoyl-CoA is almost 6-fold higher than with acetyl-CoA.
 6 Q3ZPN4 Q3ZPN4 Q8GT20 Q8GT20 Q8GT21 Q8GT21
Omega-hydroxypalmitate O-feruloyl transferase. [EC: 2.3.1.188]
Feruloyl-CoA + 16-hydroxypalmitate = CoA + 16-feruloyloxypalmitate.
  • p-coumaroyl-CoA and sinapoyl-CoA also act as substrates.
  • The enzyme is widely distributed in roots of higher plants.
 4 A0A178UGL4 A0A178UGL4 Q94CD1 Q94CD1
2-alpha-hydroxytaxane 2-O-benzoyltransferase. [EC: 2.3.1.166]
Benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA + 10-deacetylbaccatin III.
  • The enzyme was studied using the semisynthetic substrate 2-debenzoyl- 7,13-diacetylbaccatin III.
  • It will not acylate the hydroxy group at 1-beta, 7-beta, 10-beta or 13-alpha of 10-deacetylbaccatin III, or at 2-alpha or 5-alpha of taxa-4(20),11-diene-2-alpha,5-alpha-diol.
 4 Q1X7Q0 Q1X7Q0 Q9FPW3 Q9FPW3
Acetyl-CoA-benzylalcohol acetyltransferase. [EC: 2.3.1.224]
(1) Acetyl-CoA + benzyl alcohol = CoA + benzyl acetate. (2) Acetyl-CoA + cinnamyl alcohol = CoA + cinnamyl acetate.
  • The enzyme is found in flowers like Clarkia breweri, where it is important for floral scent production.
  • Unlike EC 2.3.1.84 this enzyme is active with alcohols that contain a benzyl ring.
 4 O64988 O64988 Q9SPU3 Q9SPU3
Tyramine N-feruloyltransferase. [EC: 2.3.1.110]
Feruloyl-CoA + tyramine = CoA + N-feruloyltyramine.
  • Cinnamoyl-CoA, 4-coumaroyl-CoA and sinapoyl-CoA can also act as donors.
  • Some aromatic amines can act as acceptors.
 4 D5FPG8 D5FPG8 D5HQM4 D5HQM4
Galactarate O-hydroxycinnamoyltransferase. [EC: 2.3.1.130]
Feruloyl-CoA + galactarate = CoA + O-feruloylgalactarate.
  • Sinapoyl-CoA and 4-coumaroyl-CoA can also act as donors.
 2 V7BKA6 V7BKA6
Pelargonidin 3-O-(6-caffeoylglucoside) 5-O-(6-O-malonylglucoside) 4'''-malonyltransferase. [EC: 2.3.1.214]
Malonyl-CoA + 4'''-demalonylsalvianin = CoA + salvianin.
  • Isolated from the plant Salvia splendens (scarlet sage).
 2 Q6TXD2 Q6TXD2
Spermidine disinapoyl transferase. [EC: 2.3.1.248]
2 sinapoyl-CoA + spermidine = 2 CoA + N(1),N(8)-bis(sinapoyl)-spermidine.
  • The enzyme from the plant Arabidopsis thaliana has no activity with 4-coumaroyl-CoA (cf. EC 2.3.1.249).
 2 O80467 O80467
Glucarate O-hydroxycinnamoyltransferase. [EC: 2.3.1.131]
Sinapoyl-CoA + glucarate = CoA + O-sinapoylglucarate.
  • 4-coumaroyl-CoA, feruloyl-CoA and caffeoyl-CoA can also act as donors, more slowly.
 2 V7BKA6 V7BKA6
13-hydroxylupanine O-tigloyltransferase. [EC: 2.3.1.93]
(E)-2-methylcrotonoyl-CoA + 13-hydroxylupanine = CoA + 13-((E)-2- methylcrotonoyl)oxylupanine.
  • Benzoyl-CoA and, more slowly, pentanoyl-CoA, 3-methylbutanoyl-CoA and butanoyl-CoA can act as acyl donors.
  • Involved in the synthesis of lupanine alkaloids.
 2 Q5H873 Q5H873
(Z)-3-hexen-1-ol acetyltransferase. [EC: 2.3.1.195]
Acetyl-CoA + (3Z)-hex-3-en-ol = (3Z)-hex-3-en-1-yl acetate + CoA.
  • The enzyme is resonsible for the production of (3Z)-hex-3-en-1-yl acetate, the major volatile compound released upon mechanical wounding of the leaves of Arabidopsis thaliana.
 2 Q9SRQ2 Q9SRQ2
Deacetylvindoline O-acetyltransferase. [EC: 2.3.1.107]
Acetyl-CoA + deacetylvindoline = CoA + vindoline.
  • Catalyzes the final step in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle, Catharanthus roseus.
 2 Q9ZTK5 Q9ZTK5
Vinorine synthase. [EC: 2.3.1.160]
Acetyl-CoA + 16-epivellosimine = CoA + vinorine.
  • The reaction proceeds in two stages.
  • The indole nitrogen of 16-epivellosimine interacts with its aldehyde group giving an hydroxy-substituted new ring.
  • This alcohol is then acetylated.
  • Also acts on gardneral (11-methoxy-16-epivellosimine).
  • Generates the ajmalan skeleton, which forms part of the route to ajmaline.
 2 Q70PR7 Q70PR7
Alcohol O-acetyltransferase. [EC: 2.3.1.84]
Acetyl-CoA + an alcohol = CoA + an acetyl ester.
  • Acts on a range of short-chain aliphatic alcohols, including methanol and ethanol.
 2 Q84S99 Q84S99
Spermidine dicoumaroyl transferase. [EC: 2.3.1.249]
2 4-coumaroyl-CoA + spermidine = 2 CoA + N(1),N(8)-bis(4-coumaroyl)- spermidine.
  • The enzyme from the plant Arabidopsis thaliana has no activity with sinapoyl-CoA (cf. EC 2.3.1.248).
 2 Q8GYW8 Q8GYW8
Methanol O-anthraniloyltransferase. [EC: 2.3.1.232]
Anthraniloyl-CoA + methanol = CoA + O-methyl anthranilate.
  • The enzyme from Concord grape (Vitis labrusca) is solely responsible for the production of O-methyl anthranilate, an important aroma and flavor compound in the grape.
  • The enzyme has a broad substrate specificity, and can use a range of alcohols with substantial activity, the best being butanol, benzyl alcohol, iso-pentanol, octanol and 2-propanol.
  • It can use benzoyl-CoA and acetyl-CoA as acyl donors with lower efficiency.
  • In addition to O-methyl anthranilate, the enzyme might be responsible for the production of ethyl butanoate, methyl-3-hydroxy butanoate and ethyl-3-hydroxy butanoate, which are present in large quantities in the grapes.
  • Also catalyzes EC 2.3.1.196.
 2 Q3ZPN4 Q3ZPN4
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