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CATH Superfamily 3.30.420.230

Prp8 RNase H domain, palm region

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Prp8 RNase H domain, palm region

Prp8 is the largest and most highly conserved spliceosomal protein and is considered a master regulator of the spliceosome. It forms a salt-stable complex with the Brr2 helicase that is required for spliceosome catalytic activation and disassembly and with the Snu114 GTPase that regulates Brr2 activity. Prp8 consists of a phylogenetically conserved Rnase H fold along with Prp8-specific elements. The function of this domain is to help assemble and stabilise the spliceosomal catalytic core and coordinate the activities of other splicing factors PMID:18843295.

This entry represents the palm region of the Rnase H domain which also includes the beta-hairpin thumb.

PMID:18843295

GO Diversity

Unique GO annotations
39 Unique GO terms

EC Diversity

Unique EC annotations
3 Unique EC terms

Species Diversity

Unique species annotations
1064 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 36
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 21
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 3
Unique GO: 39
Taxonomy
Unique Species: 1064