The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7739: Mercuric reductase (Hg(II) reductase)

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mercury(II) reductase. [EC: 1.16.1.1]
Hg + NADP(+) + H(+) = Hg(2+) + NADPH.
    234 A0A069DMD6 A0A081QD45 A0A094JSI3 A0A094WPK5 A0A098BN03 A0A099DCL7 A0A099ENV3 A0A0A1H0X9 A0A0A3ICU1 A0A0A3J2F3
    (224 more...)
    Dihydrolipoyl dehydrogenase. [EC: 1.8.1.4]
    Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
    • A component of the multienzyme 2-oxo-acid dehydrogenase complexes.
    • In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups.
    • It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes.
    • Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts, together with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine.
    • It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate.
    • Was first shown to catalyze the oxidation of NADH by methylene blue; this activity was called diaphorase.
    • The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
    • Formerly EC 1.6.4.3.
    22 A0A023DJI8 A0A0A2SM61 A0A0A2SWI0 A0A0D0Q5C5 A0A0G3Y3J2 A0A0M8K9I7 A0A150LLD0 A0A150N766 A0A160F864 A0A165WWY6
    (12 more...)