The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

lpxc deacetylase, domain 1

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 924: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine d...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UDP-3-O-acyl-N-acetylglucosamine deacetylase. [EC:]
UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
  • The enzyme catalyzes a committed step in the biosynthesis of lipid A.
  • Formerly EC 3.5.1.n1.
6285 A0A009F936 A0A009H3N8 A0A009HC91 A0A009HTJ3 A0A009I7D4 A0A009KAE6 A0A009KIK1 A0A009LLF6 A0A009N5M0 A0A009PHJ5
(6275 more...)
3-hydroxyacyl-[acyl-carrier-protein] dehydratase. [EC:]
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl- carrier protein] + H(2)O.
  • This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria.
  • The enzyme uses fatty acyl thioesters of ACP in vivo.
  • Different forms of the enzyme may have preferences for substrates with different chain length.
  • For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length.
  • Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyzes EC
  • Despite the differences both forms can catalyze all steps leading to the synthesis of palmitate (C16:0).
  • FabZ, but not FabA, can also accept unsaturated substrates.
  • Formerly EC, EC and EC
48 A0A076P3N9 A0A077EM91 A0A077XQD5 A0A098LW73 A0A099Y1H9 A0A0B7H2Q0 A0A0B7HB59 A0A0B7I176 A0A0B7ICH2 A0A0E2LP23
(38 more...)